JOSEPH NEWMAN
Medical Practice at 31 St, Temple, TX

5091385, Feb 25, 1992

Sep 30, 1988

7/252256

Kirpal S. Gulliya - Dallas TX
Shazib Pervaiz - Dallas TX
J. Lester Matthews - Dallas TX
Robert M. Dowben - Dallas TX
Joseph T. Newman - Dallas TX
Edward Forest - Dallas TX

Baylor Research Institute - Dallas TX

A61K 3147, A61K 31535, A61K 3154

5142248

A pre-activated therapeutic agent derived from a photoactive compound for destroying tumor or other pathogenic biological contaminants infecting animal body tissues. The activation of the photoactive compound is carried out prior to the photoactive compound is being brought into contact with the tissue to be treated. The resultant pre-activated therapeutic agent, or mixture, retains its therapeutic activity subsequent to activation. A method for preparing such a pre-activated therapeutic agent is disclosed. Methods for treating animal body tissue, either outside the body or inside the body, infected with tumors or other pathogenic biological contaminants are disclosed.

5030200, Jul 9, 1991

Nov 6, 1989

7/433024

Millard M. Judy - Dallas TX
James L. Matthews - Dallas TX
Joseph T. Newman - Dallas TX

Baylor Research Foundation - Dallas TX

A61M 3700

604 5

A method for externally eradicating infectious pathogenic contaminants, such as enveloped viruses, bacteria, trypanosomal and malarial parasites, present in body tissues, such as blood, blood components, semen, skin, and cornea, before the treated body tissues are introduced into, or transplanted onto, the body of a human or an animal. Such method includes the steps of: (1) admixing an effective, non-toxic amount of photoactive compound, which has a selectively for binding to the infectious pathogenic biological contaminants present therein, with the body tissues outside the body to produce resulting body tissues; (2) maintaining the resulting body tissues in a suitable container in which there is no net mass transfer, and (3) irradiating the resulting body tissues in the container for an effective period of time with an effective level of radiation such that the radiation penetrates the resulting body tissues and eradicates the photoactive-compound-bound contaminants present in the resulting body tissues and produces a decontaminated body tissue suitable for introducing into, or transplanting onto, the body of a human or animal.

5041078, Aug 20, 1991

Dec 21, 1989

7/454300

J. Lester Matthews - Dallas TX
Millard M. Judy - Dallas TX
Joseph T. Newman - Dallas TX
Jonathan L. Sessler - Austin TX
Anthony Harriman - Austin TX
Bhaskar G. Maiya - Hyderabad, IN

Baylor Research Foundation, a nonprofit corporation of the State of Texas - Dallas TX
Board of Regents, The University of Texas System - Austin TX

A61M 3700

604 4

The present invention demonstrates a method of photodynamic inactivation of viruses having a membranous envelope, such as Herpes simplex type 1 and Human immunodeficiency type 1 viruses. The method uses substituted sapphyrin compounds to effect viral deactivation during radiation with light at or near the absorption wavelength of the sapphyrin compound. A highly reactive species selectively toxic to infectious agents is produced. One particular sapphyrin compound useful for the practice of the invention is 8,17-bis(carboxymethyl)-3,12,13,22-tetraethyl-2,7,18,23-tetramethylsapphyr in (Sapphyrin 2). The most preferred sapphyrin sapphyrin compound for the practice of the invention is 3,8,12,13,17,22-hexaethyl-2,7,18,23-tetramethylsapphyrin (Sapphyrin 1). The method is particularly suitable for inactivation of viruses in blood and blood products.

4878891, Nov 7, 1989

Jun 25, 1987

7/067237

Millard M. Judy - Dallas TX
James L. Matthews - Dallas TX
Joseph T. Newman - Dallas TX

Baylor Research Foundation - Dallas TX

A61K 3900

604 5

A method for externally eradicating infectious pathogenic contaminants, such as enveloped viruses, bacteria, trypanosomal and malarial parasites, present in body tissues, such as blood, blood components, semen, skin, and cornea, before the treated body tisues are introduced into, or transplanted onto, the body of a human or an animal. Such method includes the steps of: (1) admixing an effective, non-toxic amount of photoactive compound, whch has a selectivity for binding to the infectious pathogenic biological contaminants present therein, with the body tissues outside the body to produce a resulting body tissues; (2) passing the resulting body tissues through an irradiating cell assembly, and (3) irradiating the resulting body tissues in the irradiating path of the cell assembly for an effective period of time with an effective level of radiation such that the radiation penetrates the resulting body tissues and eradicates the photoactive-compound-bound contaminants present in the resulting body tissues and produces a decontaminated body tissue suitable for introducing into, or transplanting onto, the body of a human or animal.

5177073, Jan 5, 1993

Apr 13, 1990

7/509036

Kirpal S. Gulliya - Dallas TX
Shazib Pervaiz - Dallas TX
J. Lester Matthews - Dallas TX
Robert M. Dowben - Dallas TX
Joseph T. Newman - Dallas TX
Edward Forest - Dallas TX

Baylor Research Institute - Dallas TX

A61K 3147, A61K 31535, A61K 3154

5142248

A therapeutic composition derived from a pre-activated photoactive compound and a conveyor for destroying tumor or other pathogenic biological contaminants infecting animal body tissues. The conveyor can either be a matrix support or an antibody. The activation of the photoactive compound to produce the pre-activated photoactive compound is carried out by the use of an activating agent. The pre-activated photoactive compound retains its therapeutic activity subsequent to activation. A method for preparing such a therapeutic composition is disclosed. Methods for treating animal body tissue, either outside the body or inside the body, infected with tumors or other pathogenic biological contaminants are disclosed.