Inventors:
Ralph S. Baric - Haw River NC, US
Anna LoBue - South San Francisco CA, US
Robert Edward Johnston - Chapel Hill NC, US
Joseph Thompson - Gainesville FL, US
Lisa Lindesmith - Apex NC, US
International Classification:
A61K 39/125, A61P 37/04, A61P 31/14
Abstract:
The invention provides immunogenic formulations comprising virus-like particles (VLPs) from two or more genoclusters and/or strains of norovirus in a pharmaceutically acceptable carrier. In representative embodiments, the formulation also comprises an adjuvant, for example, a viral adjuvant or CpG. The invention also provides methods of inducing an immune response to one or more noroviruses.