JOSEPH JOHN GLORIOSO
Medical Practice in Pittsburgh, PA
License number
Pennsylvania MD026676L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Pittsburgh, PA 15211
Personal information
See more information about JOSEPH JOHN GLORIOSO at radaris.comName
Address
Phone
739 Spring Hill Rd, Langhorne, PA 19053
2404 Old Butler Rd, New Castle, PA 16101
1024 Jancey St, Pittsburgh, PA 15206
1 Trimont Ln, West Mifflin, PA 15211
1 Trimont Ln, Pittsburgh, PA 15211
Professional information
See more information about JOSEPH JOHN GLORIOSO at trustoria.com
Professor At University Of Pittsburgh
Professor At University Of Pittsburgh
Position:
Professor at University of Pittsburgh
Location:
Greater Pittsburgh Area
Industry:
Research
Work:
University of Pittsburgh
-
Professor
University of Michigan
1976 - 1989
-
professor
Peptide Biosynthesis And Pain Therapy
Peptide Biosynthesis And Pain Therapy
US Patent:
2011011, May 12, 2011
Filed:
Sep 29, 2010
Appl. No.:
12/893352
Inventors:
DARREN P. WOLFE - PITTSBURGH PA, US
JOSEPH C. GLORIOSO - PITTSBURGH PA, US
DAVID J. FINK - ANN ARBOR MI, US
JOSEPH C. GLORIOSO - PITTSBURGH PA, US
DAVID J. FINK - ANN ARBOR MI, US
Assignee:
REGENTS OF THE UNIVERSITY OF MICHIGAN - ANN ARBOR MI
International Classification:
A61K 31/7088, C07H 21/00, C40B 40/08, C12N 15/63, A61P 29/00, A61P 25/04
US Classification:
514 44 R, 536 235, 506 17, 4353201
Abstract:
The invention provides an expression cassette comprising a DNA sequence encoding amino acids 1-99 of human preproenkephalin, a DNA sequence encoding a precursor of a carboxy-amidated peptide flanked by dibasic cleavage sites and optionally a DNA sequence encoding a marker protein (such as Enhanced Green Fluorescent Protein (GNP)) all in operable linkage and under control of a promoter. Where the encoded precursor of a carboxy-amidated peptide is an agonist for an opioid receptor, the invention further provides a method of treating neuropathic pain by administering the gene transfer vector comprising such an expression cassette to a patient. The invention also provides a method for detecting a peptide having a desired effect comprising introducing a library of DNA sequences encoding one or more precursors of carboxy-amidated peptides into host cells; expressing the carboxy-amidated peptides encoded in the library to provide expression products; and screening from the polypeptide expression products for the desired effect.
Method Of Amidated Peptide Biosynthesis And Delivery In Vivo: Endomorphin-2 For Pain Therapy
Method Of Amidated Peptide Biosynthesis And Delivery In Vivo: Endomorphin-2 For Pain Therapy
US Patent:
7825231, Nov 2, 2010
Filed:
Jun 1, 2006
Appl. No.:
11/445837
Inventors:
Darren P. Wolfe - Verona PA, US
Joseph C. Glorioso - Fox Chapel PA, US
David J. Fink - Ann Arbor MI, US
Joseph C. Glorioso - Fox Chapel PA, US
David J. Fink - Ann Arbor MI, US
Assignee:
Regents of the University of Michigan - Ann Arbor MI
International Classification:
C07H 21/04, A61K 31/711, C12N 15/12, C12N 15/62
US Classification:
536 234, 514 44 R, 4353201
Abstract:
The invention provides an expression cassette comprising a DNA sequence encoding amino acids 1-99 of human preproenkephalin, a DNA sequence encoding a precursor of a carboxy-amidated peptide flanked by dibasic cleavage sites and optionally a DNA sequence encoding a marker protein (such as Enhanced Green Fluorescent Protein (GFP)) all in operable linkage and under control of a promoter. Where the encoded precursor of a carboxy-amidated peptide is an agonist for an opioid receptor, the invention further provides a method of treating neuropathic pain by administering the gene transfer vector comprising such an expression cassette to a patient. The invention also provides a method for detecting a peptide having a desired effect comprising introducing a library of DNA sequences encoding one or more precursors of carboxy-amidated peptides into host cells; expressing the carboxy-amidated peptides encoded in the library to provide expression products; and screening from the polypeptide expression products for the desired effect.
Peptide Biosynthesis And Pain Therapy
Peptide Biosynthesis And Pain Therapy
US Patent:
8003622, Aug 23, 2011
Filed:
Sep 29, 2010
Appl. No.:
12/893255
Inventors:
Darren P. Wolfe - Pittsburgh PA, US
Joseph C. Glorioso - Pittsburgh PA, US
David J. Fink - Ann Arbor MI, US
Joseph C. Glorioso - Pittsburgh PA, US
David J. Fink - Ann Arbor MI, US
Assignee:
Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 48/00, C12N 15/00
US Classification:
514 44R, 4353201
Abstract:
The invention provides an expression cassette comprising a DNA sequence encoding amino acids 1-99 of human preproenkephalin, a DNA sequence encoding a precursor of a carboxy-amidated peptide flanked by dibasic cleavage sites and optionally a DNA sequence encoding a marker protein (such as Enhanced Green Fluorescent Protein (GFP)) all in operable linkage and under control of a promoter. Where the encoded precursor of a carboxy-amidated peptide is an agonist for an opioid receptor, the invention further provides a method of treating neuropathic pain by administering the gene transfer vector comprising such an expression cassette to a patient. The invention also provides a method for detecting a peptide having a desired effect comprising introducing a library of DNA sequences encoding one or more precursors of carboxy-amidated peptides into host cells; expressing the carboxy-amidated peptides encoded in the library to provide expression products; and screening from the polypeptide expression products for the desired effect.
Peripherally Delivered Glutamic Acid Decarboxylase Gene Therapy For Spinal Cord Injury Pain
Peripherally Delivered Glutamic Acid Decarboxylase Gene Therapy For Spinal Cord Injury Pain
US Patent:
2007020, Sep 6, 2007
Filed:
Oct 28, 2005
Appl. No.:
11/261389
Inventors:
Joseph Glorioso - Blawnox PA, US
David Fink - Ann Arbor MI, US
Darren Wolfe - Verona PA, US
David Krisky - Sewickley PA, US
David Fink - Ann Arbor MI, US
Darren Wolfe - Verona PA, US
David Krisky - Sewickley PA, US
Assignee:
University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA
Department of Veterans Affairs (024) - Washington DC
Department of Veterans Affairs (024) - Washington DC
International Classification:
A61K 48/00, C12N 15/86
US Classification:
424093200, 514044000, 435456000, 435325000
Abstract:
The invention provides a vector, preferably a herpes simplex virus (HSV) vector, comprising a polynucleotide sequence encoding a glutamic acid decarboxylase (GAD) protein. The invention also provides a stock of such vectors and a pharmaceutical composition comprising such vectors. The invention further provides a method of treating pain, such as spinal cord injury pain, in a mammal comprising administering to a mammal a vector comprising a nucleotide sequence encoding a glutamic acid decarboxylase (GAD) protein in an amount effective to treat spinal cord injury pain.
Identification Of Peptides That Facilitate Uptake And Cytoplasmic And/Or Nuclear Transport Of Proteins, Dna And Viruses
Identification Of Peptides That Facilitate Uptake And Cytoplasmic And/Or Nuclear Transport Of Proteins, Dna And Viruses
US Patent:
2007025, Nov 1, 2007
Filed:
Oct 27, 2006
Appl. No.:
11/588479
Inventors:
Paul Robbins - Mt. Lebanon PA, US
Zhibao Mi - Pittsburgh PA, US
Raymond Frizzell - Pittsburgh PA, US
Joseph Glorioso - Blawnox PA, US
Andrea Gambotto - Pittsburgh PA, US
Jeffrey Mai - Pittsburgh PA, US
Zhibao Mi - Pittsburgh PA, US
Raymond Frizzell - Pittsburgh PA, US
Joseph Glorioso - Blawnox PA, US
Andrea Gambotto - Pittsburgh PA, US
Jeffrey Mai - Pittsburgh PA, US
International Classification:
A61K 39/00, A61K 48/00, C07K 14/00, C12N 15/00, C12N 5/06
US Classification:
424184100, 424093100, 435320100, 435375000, 514002000, 530350000
Abstract:
The present invention relates to internalizing peptides which facilitate the uptake and transport of cargo into the cytoplasm and nuclei of cells as well as methods for the identification of such peptides. The internalizing peptides of the present invention are selected for their ability to efficiently internalize cargo into a wide variety of cell types both in vivo and in vitro. The method for identification of the internalizing peptides of the present invention comprises incubating a target cell with a peptide display library, isolating peptides with internalization characteristics and determining the ability of said peptide to internalize cargo into a cell.
Assay For Agonists And Antagonists Of Ion Channels And For Regulators Of Genetic Expression
Assay For Agonists And Antagonists Of Ion Channels And For Regulators Of Genetic Expression
US Patent:
2006027, Dec 7, 2006
Filed:
Jun 1, 2006
Appl. No.:
11/445835
Inventors:
Darren Wolfe - Verona PA, US
Joseph Glorioso - Fox Chapel PA, US
Rahul Srinivasan - Pittsburgh PA, US
Joseph Glorioso - Fox Chapel PA, US
Rahul Srinivasan - Pittsburgh PA, US
Assignee:
University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
C40B 30/06, C40B 40/08
US Classification:
435006000, 435007100
Abstract:
The invention provides an assay for agonists and antagonists of ion channels and for regulators of genetic expression.
Herpes Simplex Virus Vector
Herpes Simplex Virus Vector
US Patent:
7531167, May 12, 2009
Filed:
Mar 30, 2007
Appl. No.:
11/694118
Inventors:
Joseph C. Glorioso - Blawnox PA, US
Darren Wolfe - Verona AZ, US
David Krisky - Sewickley PA, US
Darren Wolfe - Verona AZ, US
David Krisky - Sewickley PA, US
Assignee:
University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
A01N 63/00, A61K 48/00
US Classification:
424 932, 424 9321
Abstract:
The invention provides a herpes simplex virus vector comprising deletions in ICP4, ICP27, and UL55.
Cell Line
Cell Line
US Patent:
8148146, Apr 3, 2012
Filed:
Apr 3, 2009
Appl. No.:
12/418062
Inventors:
Joseph C. Glorioso - Blawnox PA, US
Darren Wolfe - Verona PA, US
David Krisky - Sewickley PA, US
Darren Wolfe - Verona PA, US
David Krisky - Sewickley PA, US
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
C12N 5/00, C12N 15/00
US Classification:
435325, 435455
Abstract:
The invention provides a cell line complementing HSV ICP4, ICP27, and UL55 genes.
Cell Line
Cell Line
US Patent:
8309349, Nov 13, 2012
Filed:
Apr 3, 2009
Appl. No.:
12/418062
Inventors:
Joseph C. Glorioso - Blawnox PA, US
Darren Wolfe - Verona PA, US
David Krisky - Sewickley PA, US
Darren Wolfe - Verona PA, US
David Krisky - Sewickley PA, US
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
C12N 5/00, C12N 15/00
US Classification:
435325, 435455
Abstract:
The invention provides a cell line complementing HSV ICP4, ICP27, and UL55 genes.