Inventors:
Scott Walsh - Poughquag NY, US
Anjali Shah - North Potomac MD, US
James Mond - Silver Spring MD, US
Andrew Lees - Silver Spring MD, US
Joseph Drabick - Palmyra PA, US
Assignee:
Biosynexus Incorporated - Gaithersburg MD
International Classification:
A61K 38/48, A61P 31/04
Abstract:
The present invention relates to the conjugation of antimicrobial agents to water-soluble polymers to improve their clinical properties in terms of their pharmacokinetics, pharmacodynamics, and reduced immunogenicity. More specifically, the present invention relates to the conjugation of antimicrobial agents such as lysostaphin to poly(alkylene oxides), such as poly(ethylene glycol) (PEG).