Inventors:
Joseph G. Cremonese - Greensburg PA, US
Joseph E. Qualitz - Stow MA, US
Brookman P. March - Harwick PA, US
Michael Tolosa - Columbia MD, US
International Classification:
C12M 1/00
US Classification:
4352887, 4352891, 4352971
Abstract:
We provide a miniature, disposable reactor vessel for bioprocessing. Embodiments include a sealed vessel surrounding a filter through which spent media may be preferentially removed relative to culture cells. Preferred embodiments include an impeller shaft that is contained within the vessel and passes through the filter assembly. The impeller shaft may be engaged magnetically with a drive shaft. Combinations of these reactor vessels and methods of their use are also described.