Inventors:
Philip D. Edwards - Claymont DE
Joseph J. Lewis - West Chester PA
Charles W. Perkins - Wilmington DE
Diane A. Trainor - Glen Mills PA
Richard A. Wildonger - Morgan Hollow PA
Assignee:
ICI Americas Inc. - Wilmington DE
International Classification:
C07D23708, C07D23906, C07K 508, A61K 3702
Abstract:
The invention provides a series of novel heterocyclic ketones of formula I ##STR1## and pharmaceutically acceptable base-addition salts thereof, in which the values of R. sup. 4, L, A, X and Q have the meanings defined in the following specification. The compounds of formula I are inhibitors of human leukocytic elastase. The invention also provides pharmaceutical compositions containing a compound of formula I, or a pharmaceutically acceptable base-addition salt thereof, and processes and intermediates for the manufacture of compounds of formula I.