JOSEPH CORTESE
Broker in Quincy, MA
License number
Massachusetts 9026954
Issued Date
Jul 18, 1998
Expiration Date
Dec 9, 2016
Type
Salesperson
Address
Address
Quincy, MA 02169
Professional information
Bag
US Patent:
D266801, Nov 9, 1982
Filed:
Jan 14, 1980
Appl. No.:
6/111766
Inventors:
Joseph O. Cortese - Quincy MA
Stephen Donovan - Quincy MA
Stephen Donovan - Quincy MA
International Classification:
D0301
US Classification:
D 3 41
Small Molecule Inhibitors Of Plasmodium Falciparum Dihydroorotate Dehydrogenase
US Patent:
2011013, Jun 2, 2011
Filed:
May 7, 2009
Appl. No.:
12/991305
Inventors:
Cecilia Bastos - South Grafton MA, US
Michael L. Booker - Bridgewater MA, US
Cassandra A. Celatka - Hull MA, US
Jon C. Clardy - Jamaica Plain MA, US
Joseph Cortese - Quincy MA, US
Vishal P. Patel - Washington DC, US
Renato Skerlj - Newton MA, US
Roger C. Wiegand - Wayland MA, US
Dyann F. Wirth - Boston MA, US
Michael L. Booker - Bridgewater MA, US
Cassandra A. Celatka - Hull MA, US
Jon C. Clardy - Jamaica Plain MA, US
Joseph Cortese - Quincy MA, US
Vishal P. Patel - Washington DC, US
Renato Skerlj - Newton MA, US
Roger C. Wiegand - Wayland MA, US
Dyann F. Wirth - Boston MA, US
International Classification:
A61K 31/5377, C07D 413/04, C07D 409/04, C07D 473/00, C07D 409/14, C07D 471/04, C07D 413/14, A61K 31/4025, A61K 31/4535, A61K 31/4184, A61K 31/4155, A61K 31/496, A61K 31/52, A61K 31/454, A61K 31/437, A61K 31/422, A61P 33/06
US Classification:
51421018, 544146, 548527, 546212, 5483047, 5483657, 544379, 544277, 5483061, 546199, 546118, 548217, 5483054, 548220, 5142315, 514422, 514326, 514394, 514406, 51425213, 51426323, 514322, 514303, 514375
Abstract:
Inhibitors of dihydroorotate dehydrogenase (DHODH) for the enzyme have been identified and characterized. The inhibitors have high specificity, submicromolar efficacy against cultured parasite strains, exhibit drug-like properties, and are not overtly cytotoxic.
2-Aminoindole Compounds And Methods For The Treatment Of Malaria
US Patent:
2012023, Sep 13, 2012
Filed:
Oct 28, 2010
Appl. No.:
13/504635
Inventors:
Ralph Mazitschek - Arlington MA, US
Jon C. Clardy - Lamaica Plain MA, US
Dyann Wirth - Boston MA, US
Roger Wiegand - Wayland MA, US
Sameer Urgaonkar - Arlington MA, US
Mary Lynn Baniecki - Raleigh NC, US
Joseph Cortese - Quincy MA, US
Cassandra Celatka - Hull MA, US
Yibin Xiang - Acton MA, US
Renato Skerlj - Newton MA, US
Elyse M.J. Bourque - Watertown MA, US
Jon C. Clardy - Lamaica Plain MA, US
Dyann Wirth - Boston MA, US
Roger Wiegand - Wayland MA, US
Sameer Urgaonkar - Arlington MA, US
Mary Lynn Baniecki - Raleigh NC, US
Joseph Cortese - Quincy MA, US
Cassandra Celatka - Hull MA, US
Yibin Xiang - Acton MA, US
Renato Skerlj - Newton MA, US
Elyse M.J. Bourque - Watertown MA, US
International Classification:
A61K 31/404, C07D 405/10, C07D 413/10, A61P 33/06, C07D 491/056, A61K 31/407, C07D 403/10, A61K 31/55, C07D 209/40, A61K 31/5377
US Classification:
51421708, 548483, 514418, 548467, 544144, 5142352, 548431, 514411, 540602
Abstract:
The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)—The values and preferred values of the variables in Structural Formula I are defined herein.