JOSEPH BENJAMIN LILLEGARD
Medical Practice in Rochester, MN
License number
Pennsylvania MT205294
Category
Medicine
Type
Graduate Medical Trainee
Address
Address
2
Rochester, MN 55902
Pennsylvania
Pennsylvania
Professional information
Joseph Lillegard, Rochester MN
Work:
Mayo Medical School
200 1St St Sw, Rochester, MN 55905
200 1St St Sw, Rochester, MN 55905
Joseph B Lillegard, Rochester MN
Specialties:
Surgeon
Address:
200 1St St Sw, Rochester, MN 55905
Fumarylacetoacetate Hydrolase (Fah)-Deficient Pigs And Uses Thereof
US Patent:
2013019, Jul 25, 2013
Filed:
Mar 23, 2011
Appl. No.:
13/642213
Inventors:
Markus Grompe - Portland OR, US
Scott Nyberg - Rochester MN, US
Joseph Lillegard - Rochester MN, US
Raymond Hickey - Portland OR, US
Scott Nyberg - Rochester MN, US
Joseph Lillegard - Rochester MN, US
Raymond Hickey - Portland OR, US
Assignee:
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH - Rochester MN
OREGON HEALTH & SCIENCE UNIVERSITY - Portland OR
OREGON HEALTH & SCIENCE UNIVERSITY - Portland OR
International Classification:
C12N 5/071, G01N 33/50
US Classification:
800 3, 435370, 435 5, 435 612, 435 15, 435 21, 435 34, 800 17, 800 22
Abstract:
Described herein is the generation of Fahheterozygote pigs by homologous recombination and somatic cell nuclear transfer, and a method for producing Fahhomozygote pigs. The Fah-deficient pigs of the disclosure can be used for a variety of research and therapeutic purposes, such as for the expansion of human hepatocytes, and as large animal models of hereditary tyrosinemia type 1, cirrhosis and hepatocellular carcinoma.