Inventors:
Matthew D. Hall - Washington DC, US
Michael M. Gottesman - Bethesda MD, US
Jennifer L. Hellawell - Philadelphia PA, US
Joseph A. Ludwig - Houston TX, US
Henry M. Fales - Silver Spring MD, US
Noeris K. Salam - Jersey City NJ, US
Gergely Szakács - Budapest, HU
International Classification:
A61K 39/395, A61K 31/404, A61K 31/44, A61K 31/175, A61K 31/403, A61K 31/351, A61K 31/7068, A61K 31/704, A61K 31/437, A61K 31/7048, A61K 31/337, A61K 31/506, A61K 38/12, A61P 35/00, A61P 35/02
US Classification:
4241741, 514418, 514353, 514583, 514581, 514411, 514459, 514 49, 514 34, 514285, 514 27, 514449, 51425218, 514 199
Abstract:
Disclosed herein are drug compounds that have MDR-inverse activity and thus are effective against multidrug-resistant cells. Exemplary compounds disclosed herein have the structure:Examples of the disclosed compounds have been found to have, inter alia, efficacy in directly treating multidrug resistant cells, rendering multidrug resistant cells susceptible to other chemotherapeutics and in some instances reversing multidrug resistance.