JOSE L NAVIA, ND
Radiology at Euclid Ave, Cleveland, OH

2007003, Feb 15, 2007

Jun 21, 2006

11/471866

Jose Navia - Shaker Heights OH, US

A61F 2/24

623002130, 623001260

A stentless bioprosthetic graft for repairing a first native heart valve and a second native heart valve in a heart. The bioprosthetic graft includes a harvested homograft having a harvested mitral valve portion, a harvested distal aorta, and an extension portion made of a biocompatible material. The harvested distal aorta further includes a harvested aortic valve, a harvested aortic root, and at least a portion of a harvested atrial wall. The harvested mitral valve portion is for suturing place of the first native heart valve, and the harvested distal aorta is for suturing to a partial section of the second native heart valve. The extension portion is sutured to the homograft and is for suturing to the left atrial wall of the heart to close an incision in the left atrial wall following implantation of the harvested mitral valve portion and the harvested distal aorta of the homograft.

7914576, Mar 29, 2011

May 4, 2007

11/800454

Jose Luis Navia - Shaker Heights OH, US

The Cleveland Clinic Foundation - Cleveland OH

A61F 2/24

623 236

An apparatus for repairing a cardiac valve includes an annuloplasty ring having an expandable support member with oppositely disposed proximal and distal end portions and a main body portion between the end portions. The proximal end portion includes a plurality of wing members extending from the main body portion. Each of the wing members includes at least one hook member for embedding into a cardiac wall and a valve annulus to secure the annuloplasty ring therein. The apparatus also includes an energy delivery mechanism for selectively contracting the annuloplasty ring to restrict the valve annulus and correct valvular insufficiency. The energy delivery mechanism includes a detachable electrical lead having distal and proximal end portions. The distal end portion has a securing member for operably attaching the distal end portion to a portion of the expandable support member. The proximal end portion is operably connected to an energy delivery source.

2007003, Feb 15, 2007

Jul 14, 2006

11/486584

Jose Navia - Shaker Heights OH, US
Jose Navia - Buenos Aires, AR

A61F 2/24

623002360

An apparatus for remodeling the annulus of a cardiac valve includes a first elongate flexible member having a distal end portion and a proximal end portion interconnected by a main body portion. The distal end portion is steerable from the proximal end portion and advanceable to one side of the cardiac valve annulus via a percutaneous approach. The distal end portion includes a terminal end and a connecting section spaced apart by a predetermined length. The connecting section has a structure for disconnecting from the main body portion, in addition to a structure for interconnecting with the terminal end to form a ring of a predetermined shape adjacent the one side of the cardiac valve annulus. The distal end portion further includes a mechanism for attaching to the cardiac valve annulus so that, when the ring is formed, the distal end portion contracts and thereby remodels the annulus of the cardiac valve. The apparatus can also include a second elongate flexible member for positioning on the opposite side of the native valve annulus and which may be magnetically attracted to the first flexible member in order to attach the apparatus to the valve annulus.

2012017, Jul 12, 2012

Jan 4, 2012

13/343480

Jose L. Navia - Shaker Heights OH, US

A61F 2/24

623 237

An apparatus is provided for treating regurgitation of blood flow through a diseased heart valve. The diseased heart valve includes an annulus, anterior and posterior valve leaflets, and a subvalvular apparatus. The apparatus includes a substantially annular support member and at least one infra-annular support member securely connected thereto. The substantially annular support member has at least a first intermediate portion, a second intermediate portion, and a posterior end portion extending between the first and second intermediate portions. The posterior end portion is dimensioned for attachment to a posterior portion of the annulus of the diseased heart valve. The at least one infra-annular support member is securely connected to the substantially annular support member at a first location. The at least one infra-annular support member is dimensioned to extend below at least one of the posterior and anterior valve leaflets and across or behind at least one subvalvular structure.

2012020, Aug 9, 2012

Sep 8, 2010

13/394853

Jose L. Navia - Shaker Heights OH, US
Shengqiang Gao - Beachwood OH, US
Brian L. Davis - Moreland Hills OH, US
David J. Horvath - Euclid OH, US

A61F 2/24

623 211, 623 236

An apparatus is provided for delivering an implantable medical device to a diseased cardiac valve includes an elongated shank, a brace member, and a locking mechanism. The shank has a first end portion, a second end portion, and a first longitudinal axis extending between the end portions. The first end portion includes a rotatable annular lower support and a fixing member. The lower support includes an annular ring having oppositely disposed upper and lower surfaces and a plane extending radially between the upper and lower surfaces. The brace member includes a barrel portion operably connected to a drive system. The barrel portion includes a first end portion, a second end portion, and a second longitudinal axis extending between the end portions. The drive system includes a housing operably connected to an actuating handle. The locking mechanism is operably connected to the housing and the elongated shank.

2012009, Apr 19, 2012

Dec 23, 2011

13/336974

Jose Luis Navia - Shaker Heights OH, US

A61F 2/24, B65B 55/12, B65B 55/02, B23P 11/00

623 214, 29515, 53428, 53425

A method is provided for implanting a valve having at least one valve leaflet within the cardiovascular system of a subject. One step of the method includes preparing a substantially dehydrated bioprosthetic valve and then providing an expandable support member having oppositely disposed first and second ends and a main body portion extending between the ends. Next, the substantially dehydrated bioprosthetic valve is attached to the expandable support member so that the substantially dehydrated bioprosthetic valve is operably secured within the main body portion of the expandable support member. The expandable support member is then crimped into a compressed configuration and placed at a desired location within the cardiovascular system of the subject. Either before or after placement at the desired location, fluid or blood re-hydrates the substantially dehydrated bioprosthetic valve.

7488346, Feb 10, 2009

Jan 18, 2005

11/037499

Jose Luis Navia - Shaker Heights OH, US

The Cleveland Clinic Foundation - Cleveland OH

A61F 2/24

623 126, 623904

A method and apparatus for replacing both the native mitral valve and the native aortic valve in a heart with a stentless bioprosthetic graft is provided. The bioprosthetic graft comprises a harvested homograft that includes a mitral valve portion and an aortic valve portion, and an extension portion made of a biocompatible material. The extension portion is sutured to the homograft and is for suturing to the left atrial wall of the heart to close an incision in the left atrial wall following implantation of the mitral valve portion and the aortic valve portion of the homograft.

2007025, Nov 1, 2007

Apr 26, 2007

11/789827

Carlos Oberti - Cleveland OH, US
Jose Navia - Shaker Heights OH, US

A61F 2/84, A61F 2/90

623001110, 623001420, 623001150, 623001360

An apparatus for treating cardiovascular diseases includes an expandable support member having oppositely disposed proximal and distal end portions and a main body portion between the end portions for positioning in a blood vessel. The proximal end portion of the expandable support member includes a plurality of wing members that extend from the main body portion. Each of the wing members is for engaging at least a portion of an antrum of a cardiac chamber surrounding the blood vessel. At least a portion of the expandable support member is treated with at least one therapeutic agent for eluting into the blood vessel, the cardiac chamber, and/or cardiac tissue. The expandable support member is made of wire-mesh, and at least a portion of the expandable support member may be made of a bioabsorbable material.

7473237, Jan 6, 2009

Jan 5, 2006

11/325816

Jose L. Navia - Shaker Heights OH, US
Jose Antonio Navia - Buenos Aires, AR
Jorge Luis Jordana - Buenos Aires, AR

The Cleveland Clinic Foundation - Cleveland OH

A61M 37/00, A61M 29/00

604 613, 604 616, 604 401, 604 9601, 60410305

An apparatus and method for automatically retroperfusing a coronary vein. The apparatus includes an intraluminal graft having a tubular body extending between a proximal end and a distal end. The proximal end is for fluidly connecting to an artery to automatically supply retrograde blood for retroperfusion. The tubular body and the distal end are extendable into a vein that is fluidly connected with the coronary vein to be retroperfused. The distal end includes an expandable stent for securing the distal end in the coronary vein.