JORDAN J GREEN
Engineering in Arlington, MA
License number
Pennsylvania ET004678
Category
Engineers
Type
Engineer in Training
Address
Address
2
Arlington, MA 02476
Pennsylvania
Pennsylvania
Professional information
Electrostatic Coating Of Particles For Drug Delivery
US Patent:
2010019, Aug 5, 2010
Filed:
Mar 7, 2008
Appl. No.:
12/530330
Inventors:
Jordan J. Green - Arlington MA, US
Daniel G. Anderson - Sudbury MA, US
Robert S. Langer - Newton MA, US
Eugene Chiu - Auberndale MA, US
Elizaveta S. Leshchiner - Watertown MA, US
Daniel G. Anderson - Sudbury MA, US
Robert S. Langer - Newton MA, US
Eugene Chiu - Auberndale MA, US
Elizaveta S. Leshchiner - Watertown MA, US
International Classification:
A61K 9/32, A61K 38/02, A61K 38/16, A61K 31/70, A61K 31/7088, A61P 29/00, A61P 35/00
US Classification:
424490, 514 2, 514 12, 514 23, 514 44 R
Abstract:
A system for electrostatically coating particles is provided. The system is particularly well suited for coating charged drug delivery particles (e.g., nanoparticles, microparticles) with a coating of opposite charge. The coating may include a targeting moiety such as a small molecule ligand, peptide, protein, aptamer, etc. The coated particles are biodegradable and/or biocompatible, have a near neutral zeta (ΞΎ) potential, and are stable in serum. The invention also provides pharmaceutical compositions and kits including the inventive coated particles. Methods of preparing and using the inventive particles are also included.