Inventors:
Evan Smith - San Diego CA, US
Jonathan Tran - San Diego CA, US
International Classification:
A61K031/7056, A61K031/426
Abstract:
The present invention relates to methods for improving the pharmacokinetics of certain compounds useful as inhibitors of the HIV protease enzyme by inhibiting the enzyme activity of cytochrome P450. The present invention also relates to compositions comprising certain compounds useful as inhibitors of the HIV protease enzyme and at least one agent that inhibits the enzyme activity of cytochrome P450.