Inventors:
Lakshman R. Sehgal - Monarch Beach CA, US
Jonathan Wong - Palo Alto CA, US
Assignee:
BIOVEC, LLC. - Chicago CA
International Classification:
A61K 48/00, A61K 35/76, A61K 31/713, A61K 38/17, A61K 38/44, A61P 1/16, A61P 37/06, C12N 15/861
US Classification:
424 932, 514 44 R, 514 44 A, 514 12, 424 944, 4353201
Abstract:
A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.