JONATHAN MICHAEL DAVIS
Medical Practice in Newton, MA
License number
Pennsylvania MD030829E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Newton, MA 02459
Pennsylvania
Pennsylvania
Personal information
See more information about JONATHAN MICHAEL DAVIS at radaris.comName
Address
Phone
461 Argyle Rd, Drexel Hill, PA 19026
482 Route 6A, Yarmouth Port, MA 02675
51 Nickerson Dr, Stoughton, MA 02072
51 Dons Way, Middleboro, MA 02346
87 Alder Ln, North Falmouth, MA 02556
Professional information
Anti-Cd19 Antibodies With Reduced Immunogenicity
US Patent:
2007015, Jul 5, 2007
Filed:
Dec 29, 2006
Appl. No.:
11/648505
Inventors:
Michael Super - Lexington MA, US
Jonathan Davis - Auburndale MA, US
Pascal Stein - Boston MA, US
Jonathan Davis - Auburndale MA, US
Pascal Stein - Boston MA, US
Assignee:
Merck Patent GmbH - Darmstadt
International Classification:
A61K 39/395, C07K 16/44
US Classification:
424133100, 530388100
Abstract:
Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.
Engineered Heterodimeric Protein Domains
US Patent:
2007028, Dec 13, 2007
Filed:
Mar 23, 2007
Appl. No.:
11/728048
Inventors:
Jonathan Davis - Auburndale MA, US
James Huston - Newton Lower Falls MA, US
James Huston - Newton Lower Falls MA, US
Assignee:
Merck Patent GmbH - Darmstadt
International Classification:
C12P 21/00, C07H 21/00, C07K 14/00, C07K 16/00, C12N 1/00
US Classification:
435069100, 435243000, 530350000, 530387100, 530402000, 536023100
Abstract:
The present invention provides an engineered multidomain protein including at least two nonidentical engineered domains, each of which contains a protein-protein interaction interface containing amino acid sequence segments derived from two or more existing homologous parent domains, thereby conferring on the engineered domains assembly specificities distinct from assembly specificities of the parent domains. In particular, the engineered domains form heterodimers with one another preferentially over forming homodimers. Methods of designing and using the engineered proteins are also included.
Fibronectin Based Scaffold Domain Proteins That Bind To Pcsk9
US Patent:
8420098, Apr 16, 2013
Filed:
Apr 13, 2011
Appl. No.:
13/085864
Inventors:
Ray Camphausen - Wayland MA, US
Jonathan H. Davis - Auburndale MA, US
Sharon T. Cload - Cambridge MA, US
Fabienne M. Denhez - Arlington MA, US
Dasa Lipovsek - Cambridge MA, US
Ching-Hsiung Frederick Lo - Pennington NJ, US
Chee Meng Low - Allston MA, US
Bowman Miao - Churchville PA, US
Tracy S. Mitchell - Billerica MA, US
Rex A. Parker - Titusville NJ, US
Ginger C. Rakestraw - Cambridge MA, US
Katie A. Russo - Watertown MA, US
Doree F. Sitkoff - Dresher PA, US
Jonathan H. Davis - Auburndale MA, US
Sharon T. Cload - Cambridge MA, US
Fabienne M. Denhez - Arlington MA, US
Dasa Lipovsek - Cambridge MA, US
Ching-Hsiung Frederick Lo - Pennington NJ, US
Chee Meng Low - Allston MA, US
Bowman Miao - Churchville PA, US
Tracy S. Mitchell - Billerica MA, US
Rex A. Parker - Titusville NJ, US
Ginger C. Rakestraw - Cambridge MA, US
Katie A. Russo - Watertown MA, US
Doree F. Sitkoff - Dresher PA, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K 39/00, C07K 1/00
US Classification:
4241851, 530382
Abstract:
The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
Artificial Protein Scaffolds
US Patent:
2010002, Feb 4, 2010
Filed:
Apr 24, 2009
Appl. No.:
12/429930
Inventors:
Jonathan H. Davis - Auburndale MA, US
Assignee:
Merck Patent GmbH - Darmstadt
International Classification:
C40B 30/04, C07K 14/00, C40B 40/10, C40B 40/06, C07H 21/04, C12N 1/20
US Classification:
506 9, 530324, 506 18, 506 16, 536 231, 4352523
Abstract:
The present invention provides proteins having one or more similarities to the artificial protein Top7 or to a Top7 derivative. Proteins of the invention have one or more loops that are longer than the corresponding loops of Top7, and/or that bind to a preselected target molecule. The invention also provides nucleic acids and cells useful in producing the proteins and methods for their use.
Compounds And Methods For Fluorescently Labeling Nucleic Acids
US Patent:
2003021, Nov 13, 2003
Filed:
Feb 21, 2003
Appl. No.:
10/312264
Inventors:
Jonathan Davis - Auburndale MA, US
International Classification:
C12Q001/68
US Classification:
435/006000
Abstract:
The invention provides methods for the selection of nucleic acids that bind and thereby modulate (i.e, increase or decrease) the fluorescence intensity of a fluorophore. These selected nucleic acids may be used in methods, for example, for the detection, visualization, or quantitation of nucleic acids of interest.
Fibronectin Based Scaffold Domain Proteins That Bind Pcsk9
US Patent:
2013021, Aug 15, 2013
Filed:
Mar 15, 2013
Appl. No.:
13/835639
Inventors:
Bristol-Myers Squibb Company - , US
Jonathan H. Davis - Auburndale MA, US
Sharon T. Cload - Cambridge MA, US
Fabienne M. Denhez - Arlington MA, US
Dasa Lipovsek - Cambridge MA, US
Ching-Hsiung Frederick Lo - Pennington NJ, US
Cheen Meng Low - Allston MA, US
Bowman Miao - Chruchville PA, US
Tracy S. Mitchell - Andover MA, US
Rex A. Parker - Titusville NJ, US
Ginger C. Rackestraw - Cambridge MA, US
Katie A. Russo - Watertown MA, US
Doree F. Sitkoff - Dresher PA, US
Jonathan H. Davis - Auburndale MA, US
Sharon T. Cload - Cambridge MA, US
Fabienne M. Denhez - Arlington MA, US
Dasa Lipovsek - Cambridge MA, US
Ching-Hsiung Frederick Lo - Pennington NJ, US
Cheen Meng Low - Allston MA, US
Bowman Miao - Chruchville PA, US
Tracy S. Mitchell - Andover MA, US
Rex A. Parker - Titusville NJ, US
Ginger C. Rackestraw - Cambridge MA, US
Katie A. Russo - Watertown MA, US
Doree F. Sitkoff - Dresher PA, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07K 14/78
US Classification:
514 19, 536 235, 4353201, 43525233, 43525231, 43525421, 435348, 435325, 435365, 435357, 435358, 435369, 435367, 435352, 435 691, 514 209, 514 74
Abstract:
The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.