JONATHAN M RUBIN, MD
Radiology in Ann Arbor, MI

6535835, Mar 18, 2003

Jan 31, 2000

09/495231

Jonathan M. Rubin - Ann Arbor MI
Jeffrey Brian Fowlkes - Ann Arbor MI
Theresa Ann Tuthill - Ann Arbor MI
Anne Lindsey Hall - New Berlin WI

GE Medical Systems Global Technology Company, LLC - Waukesha WI
The Regents of the University of Michigan - Ann Arbor MI

G01B 1102

702159, 702 48

The volume of fluid flow within a vessel (VE) is measured by an ultrasound system. Ultrasound waves backscattered from the fluid within the vessel generate data from which velocity values representing components of velocity (V and V ) of the fluid flow in the scan plane (IP) are calculated. Grayscale data is correlated and the rate of decorrelation (D) of the data is calculated. The volume flow of the fluid (F) is estimated in response to the velocity signals and the rate of decorrelation (D).

5860929, Jan 19, 1999

Jun 7, 1996

8/657897

Jonathan M. Rubin - Ann Arbor MI
Ronald S. Adler - Ann Arbor MI
J. Brian Fowlkes - Ann Arbor MI
Ray Steven Spratt - San Jose CA

The Regents of the University of Michigan - Ann Arbor MI

A61B 806

600454

A method for quantitatively estimating the amount of tissue that contains moving blood using power Doppler ultrasound. A region of interest is identified from a frozen image (i. e. , a snapshot screen display created by displaying the last real-time image for a given scan). The region of interest is specified by using a pointing device (e. g. , a mouse). An object that contains one hundred percent blood flow and is located at the same depth as the region of interest, but not necessarily inside the region of interest, is identified and the corresponding power noted and designated as the reference power level. The display is adjusted to show the one hundred percent blood flow vessel in a designated color (such as, for example, green) and all other power levels are normalized to the reference power level. The fractional blood volume is quantitatively estimated by summing the normalized Doppler power levels in a region of interest and dividing the sum by the number of pixels in region of interest. The numerical result for the specified region of interest may be shown on the display of the ultrasound scanner.

2013034, Dec 26, 2013

May 9, 2013

13/890906

Grant Kruger - Ann Arbor MI, US
Brian Thelen - Ann Arbor MI, US
Jonathan Rubin - Ann Arbor MI, US
Leo Koziol - Canton MI, US
Robert Brook - Canton MI, US
Mainak Mitra - Ann Arbor MI, US

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI

A61B 8/00, A61B 8/08

600445, 600443

An ultrasound imaging system uses a magnetic linear motor driven ultrasound scanner, with accurate track and hold operation and/or other motion feedback, to scan a two dimensional or three dimensional area of a sample. The scanner is implemented in a low-power and low-bandwidth handheld device and is connected with a remote image processing system that receives raw data and performs full ultrasound image analysis and creation, allowing the handheld to be used for scanning, pre-processing, and display.

6558328, May 6, 2003

Jun 4, 2001

09/871881

Richard Yung Chiao - Menomonee Falls WI
Jonathan Matthews Rubin - Ann Arbor MI
Kai Erik Thomenius - Clifton Park NY

General Electric Company - Niskayuna NY

A61B 800

600447

A method and an apparatus for perfusion imaging using coded excitation. Bursting pulses are scanned over the region of interest in one or more frames followed by scanning one or more encoded imaging pulses in each subsequent frame. The bursting pulse is intended to break contrast micro-bubbles within a transmit focal zone and therefore should have high mechanical index and low frequency. The basic concept is to use a very low-amplitude encoded pulse train to image the contrast agents. The low amplitude prevents the contrast bubbles in the transmit focal zone from being destroyed while imaging, and the coded excitation provides the necessary signal-to-noise ratio. The imaging pulses are transmitted during refilling of the transmit focal zone with contrast agent subsequent to transmission of the bursting pulse into the transmit focal zone. On receive, the receive vectors are decoded to form a compressed pulse.

6575927, Jun 10, 2003

May 12, 1999

09/310673

William F. Weitzel - Ypsilanti MI
Jonathan M. Rubin - Ann Arbor MI
Joseph M. Messana - Ann Arbor MI

The Regents of the University of Michigan - Ann Arbor MI

A61M 500

604 8, 604 401, 604 504, 604 611, 210646, 210 87, 7386118

A system and method are provided for determining the performance of a vessel, such as a hemodialysis access, which communicates blood between two locations of a patient. A conduit, such as an external dialysis circuit or an intravascular catheter, is provided in fluid communication with the vessel, and has a diversion point for diverting blood from the vessel into the conduit. The system further includes means for determining a flow rate of the diverted blood through the conduit. A first sensor in communication with the vessel generates at least one signal that is a function of a blood flow rate in the vessel downstream from the diversion point, wherein the downstream flow rate depends on the determined conduit flow rate and the performance of the vessel can be determined based on the signal. In addition, a processor can be provided in communication with the first sensor for determining a flow rate in the vessel upstream from the diversion point from the signal and the conduit flow rate. In a preferred embodiment, the first sensor is an ultrasonic sensor, and the at least one signal represents a time-averaged mean Doppler velocity of blood flow.

7318804, Jan 15, 2008

Dec 9, 2003

10/731302

William F. Weitzel - Ypsilanti MI, US
Kang Kim - Ann Arbor MI, US
Matthew O'Donnell - Ann Arbor MI, US
Jonathan M. Rubin - Scio Township MI, US
Hua Xie - Ann Arbor MI, US
Xunchang Chen - Ann Arbor MI, US

The Regents of the University of Michigan - Ann Arbor MI

A61B 8/00

600438, 600443

Methods and systems for measuring mechanical property of a vascular wall and a method and system for determining health of a vascular structure are provided wherein local deformation of a vessel wall resulting from physiologic pressures with altered transmural forces is measured. A non-invasive free-hand ultrasound scanning-procedure was performed to apply external force, comparable to the force generated in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. When the applied pressure matched the internal baseline diastolic pressure, strain and strain rate increased by a factor of 10 over a cardiac cycle. Radial arterial strain was assessed in the vessel wall over the entire deformation procedure using a phase-sensitive, two-dimensional speckle-tracking algorithm. An elastic modulus reconstruction procedure was developed to estimate the non-linear elastic properties of the vascular wall.

7154987, Dec 26, 2006

Sep 8, 2005

11/222105

Jonathan M. Rubin - Ann Arbor MI, US
Benoit Desjardins - Ann Arbor MI, US
J. Brian Fowlkes - Ann Arbor MI, US
Srini Tridandapani - Saline MI, US

The Regents of the University of Michigan - Ann Arbor MI

G01N 23/083

378 8, 378 4

An x-ray CT system performs a scan by acquiring projection views from which an image is reconstructed. In a prospective embodiment, the correlation of adjacent views is calculated as the scan is performed and is used to detect subject motion as the scan is being performed. In a retrospective embodiment, the correlation of adjacent views is calculated and is used to detect subject motion after the scan is completed. In the first embodiment substitute projection views are acquired by continuing the scan and in the second embodiment redundant projection views acquired during the scan are substituted until the best possible image is produced.

8167804, May 1, 2012

Oct 2, 2007

11/866000

Kang Kim - Ann Arbor MI, US
William F. Weitzel - Ypsilanti MI, US
Jonathan M. Rubin - Ann Arbor MI, US
Congxian Jia - Ann Arbor MI, US
Matthew O'Donnell - Seattle WA, US
Theodore J. Kolias - Ann Arbor MI, US

The Regents of the University of Michigan - Ann Arbor MI

A61B 8/00

600438, 600407, 600437, 600441, 600448, 600480, 600481, 600439

An optimized elastic modulus reconstruction procedure can estimate the nonlinear elastic properties of vascular wall from intramural strain and pulse wave velocity (PWV) measurements. A noninvasive free-hand ultrasound scanning procedure is used to apply external force, comparable to the force in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. PWV is estimated at the same location where intramural strain is measured. The reconstructed elastic modulus is optimized and the arterial elastic modulus can be determined and monitored using a simple dual elastic modulus reconstruction procedure.

2008028, Nov 20, 2008

May 16, 2007

11/803966

Anne Lindsay Hall - New Berlin WI, US
Jonathan Matthews Rubin - Ann Arbor MI, US
J. Brian Fowlkes - Ann Arbor MI, US
Oliver Daniel Kripfgans - Ann Arbor MI, US
Paul L. Carson - Ann Arbor MI, US

A61B 8/06

600454

An ultrasound system comprises an ultrasound probe, a user interface and a processor. The ultrasound probe comprises a transducer face emitting ultrasound beams into a patient. The probe acquires a volume of ultrasound data comprising a blood vessel. The user interface defines a surface on an image that is based on the volume. The surface bisects the blood vessel and further comprises a plurality of points where at least some of the points are located at unequal distances with respect to the transducer face. The processor is configured to steer a subset of the ultrasound beams to intersect the surface at a 90 degree angle and calculate volumetric flow information through the blood vessel based on the ultrasound data corresponding to the surface.

2008017, Jul 24, 2008

Jan 18, 2008

12/016505

Xueding Wang - Canton MI, US
David Chamberland - Medford OR, US
Paul Carson - Ann Arbor MI, US
Brian Fowlkes - Ann Arbor MI, US
Ron Bude - Plymouth MI, US
Blake Roessler - Ann Arbor MI, US
Jonathan Rubin - Ann Arbor MI, US
Nicholas A. Kotov - Ypsilanti MI, US

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI

G01N 29/00

73602

A system and method for photoacoustic tomography of a sample, such as a mammalian joint, includes a light source configured to deliver light to the sample, an ultrasonic transducer disposed adjacent to the sample for receiving photoacoustic signals generated due to optical absorption of the light by the sample, a motor operably connected to at least one of the sample and the ultrasonic transducer for varying a position of the sample and the ultrasonic transducer with respect to one another along a scanning path, and a control system in communication with the light source, the ultrasonic transducer, and the motor for reconstructing photoacoustic images of the sample from the received photoacoustic signals.