Inventors:
Jonathan Kurtis - Providence RI, US
Mario Jiz - Providence RI, US
Haiwei Wu - Lincoln RI, US
Sunthorn Pond-Tor - Cranston RI, US
International Classification:
A61K 39/00, A61P 33/00, A61P 37/04, A61K 38/39
Abstract:
The method for large scale production of a full length Schistosomal paramyosin coiled coil dimer composition is carried out by providing a composition comprising recombinant paramyosin, contacting the composition with a strand separation agent to remove paramyosin fragments and other contaminants. The purified paramyosin is used in vaccines for humans and bovine animals to induce immunity against schistosomal infection.