Inventors:
Jochen Buck - Old Greenwich CT, US
Lonny Levin - New York NY, US
Jonathan Zippin - New York NY, US
Assignee:
CORNELL UNIVERSITY - Ithaca NY
International Classification:
A61K 49/00, C12Q 1/00, C12Q 1/02, A61K 31/7088, A61K 31/496, A61P 17/00, A61K 31/421, A61K 31/4184, A61K 31/4025, A61K 31/4015, A61P 17/06, A61K 39/395, A61K 31/427
US Classification:
424 91, 4241581, 435 4, 435 29, 514 44 R, 5142541, 514371, 514376, 514395, 514422, 514424
Abstract:
Soluble adenylyl cyclase (sAC) is implicated in proliferation of keratinocytes. Inhibitors of sAC are useful for the treatment and/or prevention of psoriasis and other hyperproliferative skin disorders. Assays to identify such compounds are also described.