Inventors:
Jonathan F. Tait - Seattle WA
David S. Brown - Auburn WA
Assignee:
University of Washington - Seattle WA
International Classification:
C07K 2102
US Classification:
536 235, 536 231, 435 691, 435 697, 4353201, 530300, 530350, 530324
Abstract:
Modified annexins having an N-terminal chelation site comprising an amino acid extension are disclosed. The amino acid extension includes an amino acid sequence X -Gly-X , where X and X are selected from Gly and Cys, where at least one of X or X is Cys. Radionuclides are readily chelated by the modified annexins to provide radiolabeled annexins useful in imaging vascular thrombi and apoptosis in vivo.