Inventors:
Ari M. Melnick - New York NY, US
Jonathan D. Licht - Northbrook IL, US
Gilbert Privé - Toronto, CA
Khaja Farid Ahmad - San Francisco CA, US
International Classification:
A61K 38/00, A61K 51/00
Abstract:
Provided are peptides or mimetics that block corepressor binding to a BCL6 lateral groove. Also provided are methods of blocking corepressor binding to the BCL6 lateral groove. Additionally, methods of inhibiting BCL6 repression in a mammalian, cell, and methods of treating a mammal with cancer are provided.