JONATHAN C CRUZ
Broker in Boston, MA
License number
Massachusetts 9519005
Issued Date
Mar 4, 2011
Expiration Date
Feb 4, 2014
Type
Salesperson
Address
Address
Boston, MA 02118
Professional information
Jonathan Cruz - Hyde Park, MA
Work:
ROXY NIGHT CLUB
Security Guard MARINE APPRENTICE PROGRAM
Apprentice MARINE APPRENTICE PROGRAM - Boston, MA
Maintenance Technician Assistant MARSHALL'S - Boston, MA
Intern Sales Associate Dunkin Donuts - Roslindale, MA
Crew Member
Security Guard MARINE APPRENTICE PROGRAM
Apprentice MARINE APPRENTICE PROGRAM - Boston, MA
Maintenance Technician Assistant MARSHALL'S - Boston, MA
Intern Sales Associate Dunkin Donuts - Roslindale, MA
Crew Member
Education:
ENGLISH HIGH SCHOOL - Boston, MA
High School Diploma
High School Diploma
Compounds And Methods For Treating Neurodegenerative Disorders
US Patent:
2005001, Jan 20, 2005
Filed:
Jul 24, 2003
Appl. No.:
10/625986
Inventors:
Jonathan Cruz - Boston MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
A61K031/365
US Classification:
514473000
Abstract:
Disclosed are improved methods of treating individuals with Alzheimer's disease (AD) as well as methods to diagnose AD in an individual. Also included are compounds and methods of identifying compounds to treat AD. The present invention also discloses methods for decreasing the phosphorylation of amyloid precursor protein (APP), including inhibiting phosphorylation of amino acid residue tyrosine 668 of APP and for reducing cleavage of APP. The present invention further discloses transgenic (Tg), non-human animals and cells expressing a p25 transgene that are models of neurodegenerative diseases. Embodiments of the present invention are directed to methods wherein the Tg animals and Tg cells of the invention are used to screen for modulators of neurodegenerative disorders. The Tg animals and cells of the present invention are useful for elucidating the mechanisms of neurodegenerative disorders.