Inventors:
Toren Finkel - Bethesda MD, US
Jonathan M. Hill - Bethesda MD, US
Arshed A. Quyyumi - Atlanta GA, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 49/00, A61K 48/00, A61K 35/12, A61K 35/14, G01N 33/53, C12N 5/00, C12N 5/07, A01N 1/02
US Classification:
424 91, 435 2, 435 4, 435 71, 435 72, 435 721, 435325, 435332, 435343, 435373, 435375, 424 932, 424520, 424529
Abstract:
A method for diagnosing decreased vascular function is disclosed. The method includes assaying the number of endothelial progenitor cells. A method for detecting increased cardiovascular risk is also disclosed, as is a method for diagnosing atherosclerosis. In one example, the methods include assaying the number of endothelial progenitor cells. A method for treating a subject with decreased vascular function is disclosed. The method includes administering a therapeutically effective amount of endothelial progenitor cells to the subject. In one embodiment, the subject has atherosclerosis.