Inventors:
Perry Hackett - Shoreview MN, US
Aidas Nasevicius - Roseville MN, US
Shannon Wadman - Minneapolis MN, US
Jeffrey Essner - Minneapolis MN, US
Jon Larson - Minneapolis MN, US
Karl Clark - Ramsey MN, US
Sharon Roberg-Perez - Minneapolis MN, US
Stephen Ekker - St. Paul MN, US
International Classification:
A61K048/00, A61K038/18, C12Q001/68, A01K067/027, C07H021/04, C12P021/02, C12N005/06, C07K014/475
US Classification:
514/012000, 514/044000, 514/081000, 514/090000, 435/006000, 435/069100, 435/320100, 435/325000, 530/350000, 536/023200, 544/081000, 544/082000, 800/018000, 800/020000
Abstract:
The application is related to the field of nucleic acids with identified utility, and more particularly, to genes, related nucleic acids, their complements, polypeptides, and methods of using the same for blood vessel, cartilage, and bone formation, as well as inhibition thereof. The application describes discoveries made using the zebrafish embryo technique, as well as other techniques that are described herein. The discoveries include genes, related nucleic acids, and their complements, as well as sequences, polypeptides, other molecules, and methods for using them, e.g., TDE1, PTV, MOESIN, and HKE4. Also described are polypeptide products, inhibition of expression, administration of materials and products, screening procedures, and techniques for making drugs. Moreover, uses of these discoveries in appropriate contexts are set forth.