JON A WOLFF, MD
Medical Practice at Highland Ave, Madison, WI
License number
Wisconsin 29399
Category
Medical Practice
Type
Pediatrics
Address
Address
1500 Highland Ave, Madison, WI 53705
Phone
(608) 263-5993
(608) 833-6932 (Fax)
(608) 829-5238
(608) 833-6932 (Fax)
(608) 829-5238
Organization information
See more information about JON A WOLFF at bizstanding.comJon Wolff MD
1500 Highland Ave, Madison, WI 53705
Industry:
Genetic Medicine, Pediatrician
Phone:
(608) 263-5993 (Phone)
Jon Asher Wolff
Jon A Wolff
1500 Highland Ave, Madison, WI 53705
Status:
Inactive
Industry:
Grant Reviewer
Medical Doctor:
Gregory M. Rice Medical Doctor, inactive
Professional information
Generation Of Antibodies Through Lipid Mediated Dna Delivery
US Patent:
5703055, Dec 30, 1997
Filed:
Jan 26, 1994
Appl. No.:
8/187630
Inventors:
Philip L. Felgner - Rancho Santa Fe CA
Jon Asher Wolff - Madison WI
Gary H. Rhodes - Leucadia CA
Robert Wallace Malone - Davis CA
Dennis A. Carson - Del Mar CA
Jon Asher Wolff - Madison WI
Gary H. Rhodes - Leucadia CA
Robert Wallace Malone - Davis CA
Dennis A. Carson - Del Mar CA
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
Vical Incorporated - San Diego CA
Vical Incorporated - San Diego CA
International Classification:
A61K 4800, A61K 39395, A61K 3900, C12P 2106
US Classification:
514 44
Abstract:
A method is disclosed for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy. In particular, a method is disclosed for the generation of detectable antibodies by the direct administration to a tissue in a mammal a DNA sequence encoding a immunogen where the DNA is complexed to a cationic lipid.
Compositions And Methods For Drug Delivery Using Amphiphile Binding Molecules
US Patent:
2004013, Jul 15, 2004
Filed:
Jan 12, 2004
Appl. No.:
10/755784
Inventors:
Jon Wolff - Madison WI, US
James Hagstrom - Madison WI, US
Sean Monahan - Madison WI, US
Vladimir Budker - Middleton WI, US
David Rozema - Madison WI, US
Paul Slattum - Madison WI, US
James Hagstrom - Madison WI, US
Sean Monahan - Madison WI, US
Vladimir Budker - Middleton WI, US
David Rozema - Madison WI, US
Paul Slattum - Madison WI, US
International Classification:
A61K048/00, A61K031/724, C12N015/85
US Classification:
435/455000, 514/044000, 514/054000
Abstract:
The present invention relates to the delivery of desired compounds (e.g., nucleic acids) into cells using noncovalent delivery systems which include complexing nucleic acids, amphipathic binding agents, and amphiphiles.
Intravascular Delivery Of Non-Viral Nucleic Acid
US Patent:
2004025, Dec 23, 2004
Filed:
May 4, 2004
Appl. No.:
10/838622
Inventors:
Jon Wolff - Madison WI, US
Vladimir Budker - Middleton WI, US
James Hagstrom - Middleton WI, US
Sean Monahan - Madison WI, US
David Rozema - Madison WI, US
Paul Slattum - Madison WI, US
Vladimir Budker - Middleton WI, US
James Hagstrom - Middleton WI, US
Sean Monahan - Madison WI, US
David Rozema - Madison WI, US
Paul Slattum - Madison WI, US
International Classification:
A61K048/00, C12N015/85
US Classification:
514/044000, 435/455000
Abstract:
Disclosed is a system for providing nucleic acid expression in a cell. A polynucleotide is inserted into a mammalian vasculature. The vessel permeability is increased and the polynucleotide is delivered to the cell where it enhances the endogenous properties of the cell.
Intravascular Delivery Of Non-Viral Nucleic Acid
US Patent:
2002013, Sep 26, 2002
Filed:
Jul 27, 2001
Appl. No.:
09/917154
Inventors:
Sean Monahan - Madison WI, US
Jon Wolff - Madison WI, US
James Hagstrom - Middleton WI, US
Vladimir Budker - Middleton WI, US
David Rozema - Madison WI, US
Paul Slattum - Madison WI, US
Jon Wolff - Madison WI, US
James Hagstrom - Middleton WI, US
Vladimir Budker - Middleton WI, US
David Rozema - Madison WI, US
Paul Slattum - Madison WI, US
International Classification:
A61K048/00
US Classification:
514/044000
Abstract:
Disclosed is a system for providing nucleic acid expression in a cell. A polynucleotide is inserted into a mammalian vasculature. The vessel permeability is increased and the polynucleotide is delivered to the cell where it enhances the endogenous properties of the cell.
Novel Methods For The Delivery Of Polynucleotides To Cells
US Patent:
2003023, Dec 25, 2003
Filed:
Jun 16, 2003
Appl. No.:
10/462138
Inventors:
Sean Monahan - Madison WI, US
Lisa Nader - Madison WI, US
Jon Wolff - Madison WI, US
Vladimir Budker - Middleton WI, US
James Hagstrom - Middleton WI, US
Lisa Nader - Madison WI, US
Jon Wolff - Madison WI, US
Vladimir Budker - Middleton WI, US
James Hagstrom - Middleton WI, US
International Classification:
A61K048/00, C12N015/85
US Classification:
435/455000, 514/044000
Abstract:
Process are described for the delivery of a polynucleotide to a cell. The process comprises forming a salt stable complex between the polynucleotide and a cationic surfactant. Ternary complexes are also made by associating an amphipathic compound with the binary complex. The resultant complexes are suitable for delivery of the polynucleotide to cells in vitro and in vivo.
Method Of Grafting Genetically Modified Cells To Treat Defects, Disease Or Damage Of The Central Nervous System
US Patent:
5762926, Jun 9, 1998
Filed:
Jun 5, 1995
Appl. No.:
8/464397
Inventors:
Fred H. Gage - La Jolla CA
Malcolm Schinstine - San Diego CA
Jasodhara Ray - San Diego CA
Theodore Friedmann - La Jolla CA
Michael D. Kawaja - Toronto, CA
Michael B. Rosenberg - San Diego CA
Jon A. Wolff - Madison WI
Malcolm Schinstine - San Diego CA
Jasodhara Ray - San Diego CA
Theodore Friedmann - La Jolla CA
Michael D. Kawaja - Toronto, CA
Michael B. Rosenberg - San Diego CA
Jon A. Wolff - Madison WI
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C12N 500, C12N 1509, C12N 1579, A61K 4800
US Classification:
424 9321
Abstract:
Methods of genetically modifying donor cells by gene transfer for grafting into the central nervous system to treat defective, diseased or damaged cells are disclosed. The modified donor cells produce functional molecules that effect the recovery or improved function of cells in the CNS. Methods and vectors for carrying out gene transfer and grafting are described.
Process Of Transfecting A Cell With A Polynucleotide Mixed With An Amphipathic Compound And A Dna-Binding Protein
US Patent:
5744335, Apr 28, 1998
Filed:
Sep 19, 1995
Appl. No.:
8/530598
Inventors:
Jon A. Wolff - Madison WI
Jeffery Fritz - Nashville TN
Vladimir Budker - Madison WI
James Hagstrom - Madison WI
Jeffery Fritz - Nashville TN
Vladimir Budker - Madison WI
James Hagstrom - Madison WI
Assignee:
Mirus Corporation - Madison WI
International Classification:
C12N 1564, A61K 3816, C07H 2100
US Classification:
4351723
Abstract:
The present invention provides a process of transfecting a cell with a polynucleotide mixed with one or more amphipathic compounds and an effective amount of a DNA-binding protein. Exemplary and preferred DNA-binding proteins are H1, H2A, and H2B. Exemplary and preferred amphipathic compounds are cationic amphipathic compounds.
Process Of Making A Compound By Forming A Polymer From A Template Drug
US Patent:
2006002, Feb 2, 2006
Filed:
Sep 26, 2005
Appl. No.:
11/235000
Inventors:
Vladimir Trubetskoy - Middleton WI, US
Jon Wolff - Madison WI, US
Paul Slattum - Madison WI, US
Lisa Hanson - Madison WI, US
Vladimir Budker - Middleton WI, US
James Hagstrom - Middleton WI, US
Jon Wolff - Madison WI, US
Paul Slattum - Madison WI, US
Lisa Hanson - Madison WI, US
Vladimir Budker - Middleton WI, US
James Hagstrom - Middleton WI, US
International Classification:
C12N 15/85, C08G 63/91
US Classification:
435455000, 525054200
Abstract:
A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
Charge Reversal Of Polyion Complexes
US Patent:
2008023, Sep 25, 2008
Filed:
Jun 3, 2008
Appl. No.:
12/132030
Inventors:
Jon A. Wolff - Madison WI, US
Vladimir S. Trubetskoy - Madison WI, US
Aaron G. Loomis - Stoughton WI, US
Paul M. Slattum - Madison WI, US
Sean D. Monahan - Madison WI, US
James E. Hagstrom - Madison WI, US
Vladimir G. Budker - Madison WI, US
Vladimir S. Trubetskoy - Madison WI, US
Aaron G. Loomis - Stoughton WI, US
Paul M. Slattum - Madison WI, US
Sean D. Monahan - Madison WI, US
James E. Hagstrom - Madison WI, US
Vladimir G. Budker - Madison WI, US
International Classification:
A61K 31/70
US Classification:
514 44
Abstract:
An ionic polymer is utilized in “recharging” (another layer having a different charge) a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The resulting recharged complex can be formed with an appropriate amount of positive or negative charge such that the resulting complex has the desired net charge.
Intravascular Delivery Of Nucleic Acid
US Patent:
7015040, Mar 21, 2006
Filed:
Dec 10, 2004
Appl. No.:
11/008856
Inventors:
Jon A. Wolff - Madison WI, US
Vladimir G. Budker - Middleton WI, US
James E. Hagstrom - Middleton WI, US
Julia Hegge - Monona WI, US
Hans Herweijer - Madison WI, US
Vladimir G. Budker - Middleton WI, US
James E. Hagstrom - Middleton WI, US
Julia Hegge - Monona WI, US
Hans Herweijer - Madison WI, US
Assignee:
Mirus Bio Corporation - Madison WI
International Classification:
C12N 15/88
US Classification:
435458, 435 691, 514 44, 536 231
Abstract:
Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the vessel allows delivery of the nucleic acid to an extravascular parenchymal cell.