JOHN WING FAN
Medical Practice in San Diego, CA
License number
Pennsylvania MD450387
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
San Diego, CA 92128
Pennsylvania
Pennsylvania
Professional information
Solid Dispersion Of Alpha-Ketoamide Derivatives
US Patent:
2012001, Jan 19, 2012
Filed:
Jul 13, 2011
Appl. No.:
13/182218
Inventors:
Andrew Xian CHEN - San Diego CA, US
John FAN - San Diego CA, US
Masazumi YAMAGUCHI - Kobe-shi, JP
John FAN - San Diego CA, US
Masazumi YAMAGUCHI - Kobe-shi, JP
Assignee:
SENJU PHARMACEUTICAL CO., LTD. - Osaka-shi
International Classification:
A61K 31/27, A61P 25/28, A61P 19/02, A61P 21/00, A61P 27/12, A61P 7/02, A61P 25/00, A61P 9/10
US Classification:
514485
Abstract:
A solid dispersion comprising ((1S)-1-((((1S)-1-benzyl-2,3-dioxo-3-(cyclopropylamino)propyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester made amorphous in the presence of a water-soluble cellulosic polymer has improved storage stability. The solid dispersion also has improved solubility for an improved bioavailability.