Inventors:
Alexander Smith - Cary NC, US
Joe Cobb - Greenville NC, US
John Bettis - Greenville NC, US
William Stagner - Apex NC, US
Brad Gold - Greenville NC, US
International Classification:
A61K 9/24, A61K 31/165, A61P 29/00
Abstract:
The invention provides a rapidly disintegrating and dissolving multilayer tablet comprising at least a tetracycline in a first layer, a buffer in a second layer, and optionally, an inert layer separating the first and second layers. The multilayer tablets of the invention are useful for treating or preventing mucositis, when administered topically to the oral cavity.