Inventors:
Leslie Garry Adams - College Station TX
Richard P. Crawford - College Station TX
Donald S. Davis - College Station TX
Thomas A. Ficht - College Station TX
Roger Smith - College Station TX
Blair A. Sowa - Bryan TX
Joe W. Templeton - College Station TX
John D. Williams - College Station TX
Albert M. Wu - Tao-yuan, TW
Assignee:
The Texas A&M University System - College Station TX
International Classification:
A61K 3910, C12N 121
Abstract:
The present invention is an improved vaccine against Brucella abortus which permits differentiation between vaccinated and field strain infected cattle. The vaccine can be administered in two different forms: (1) cell envelopes isolated from an O polysaccharide antigen deficient, stable transposon mutant of B. abortus or (2) an O polysaccharide antigen deficient, stable transposon mutant of B. abortus.