Inventors:
Cathrine Rein Carlson - Oslo, NO
Kjetil Tasken - Rykkinn, NO
John Scott - Portland OR, US
International Classification:
A61K 35/12, C12N 9/12, C07K 16/18, C12N 15/11, C12P 21/04, A61P 37/00, C12Q 1/48, C12N 5/06, A61K 38/43, A61K 31/70
US Classification:
424 9321, 435194, 5303879, 536 232, 435 691, 435375, 424 945, 514 44, 435 15
Abstract:
A PKA I anchoring disrupting molecule or AKAP mimic, wherein said molecule or mimic is a polypeptide which comprises the following amino acid sequence: XXXY A XXL A XXXI XXXXX(sequence (1)) or a peptidomimetic or analogue thereof is provided. Also provided are antibodies to the molecule, nucleic acid molecules comprising a sequence encoding the molecule and pharmaceutical compositions. A method of altering the PKA type I signalling pathway in a cell by administration of the anchoring disruption molecule or AKAP mimic, in particular to treat immunosuppressive disorders, proliferative diseases or autoimmune diseases is also provided.