JOHN STEWART MAIER
Medical Practice in Pittsburgh, PA
License number
Pennsylvania MD420065
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Pittsburgh, PA 15217
Professional information
Spectroscopic Systems And Methods For Classifying And Pharmaceutically Treating Cells
US Patent:
8379197, Feb 19, 2013
Filed:
Aug 3, 2009
Appl. No.:
12/462350
Inventors:
Janice Panza - Pittsburgh PA, US
John S. Maier - Pittsburgh PA, US
Jason Neiss - Pittsburgh PA, US
John S. Maier - Pittsburgh PA, US
Jason Neiss - Pittsburgh PA, US
Assignee:
ChemImage Corporation - Pittsburgh PA
International Classification:
G01J 3/00, G01J 3/44
US Classification:
356301, 356300
Abstract:
A system and method to distinguish normal cells from cells having undergone a biochemical change. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference spectral data sets for normal cells and a second plurality of reference spectral data sets for cells having undergone a biochemical change. A sample is irradiated to generate a target spectral data set based on photons absorbed, reflected, emitted, or scattered by the sample. The target spectral data set is transformed into a pre-determined vector space. A distribution of transformed data is analyzed in the pre-determined vector space. Based on the analysis, the sample is classified as containing normal cells, cells having undergone a biochemical change, and combinations thereof. The method includes treating the sample with a pharmaceutical agent prior to irradiating the sample and using the classification to assess the efficiency of the pharmaceutical agent.
Distinguishing Between Renal Oncocytoma And Chromophobe Renal Cell Carcinoma Using Raman Molecular Imaging
US Patent:
7755757, Jul 13, 2010
Filed:
Sep 8, 2008
Appl. No.:
12/206467
Inventors:
John Maier - Pittsburgh PA, US
Jeffrey Cohen - Pittsburgh PA, US
Shona Stewart - Pittsburgh PA, US
Jeffrey Cohen - Pittsburgh PA, US
Shona Stewart - Pittsburgh PA, US
Assignee:
ChemImage Corporation - Pittsburgh PA
International Classification:
G01J 3/44, G01N 21/65
US Classification:
356301, 356 73
Abstract:
A system and method to provide a diagnosis of the renal disease state of a test renal sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known renal sample and an associated known renal disease state. A test renal sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a renal disease state of the test renal sample is provided. The renal disease state includes renal oncocytoma or chromophobe renal carcinoma disease state.
System And Method For Instrument Correction Using Transmission Efficiency
US Patent:
2011020, Aug 25, 2011
Filed:
Feb 11, 2011
Appl. No.:
12/931836
Inventors:
John Maier - Pittsburgh PA, US
Michael Fuhrman - Pittsburgh PA, US
Michael Fuhrman - Pittsburgh PA, US
Assignee:
Chemimage Corporation - Pittsburgh PA
International Classification:
G06F 19/00
US Classification:
702104
Abstract:
A system and method for providing an instrument response correction based on transmission efficiency. Test data may be acquired at a first operating point. A look-up table may be searched to determine an instrument response correction. This look-up table may comprise a plurality of instrument response corrections, each instrument response correction corresponding to an intensity response of the sample at an operating point. The instrument response correction may then be applied to correct for environmental factors that may affect transmission efficiency. A system may comprise an illumination source, a collection optics, a tunable filter, a detector, a sensor and a control unit. The detector may detect interacted photons generated by illuminating a sample and generate test data. The sensor may be configured to sense an operating condition and transmit this information to the control unit which is configured to search a look-up table to determine the appropriate instrument response correction.
Non-Invasive Biochemical Analysis
US Patent:
7330746, Feb 12, 2008
Filed:
Jun 7, 2005
Appl. No.:
11/146458
Inventors:
Joseph E. Demuth - Pittsburgh PA, US
Patrick J. Treado - Pittsburgh PA, US
John S. Maier - Pittsburgh PA, US
Jeffrey K. Cohen - Pittsburgh PA, US
Patrick J. Treado - Pittsburgh PA, US
John S. Maier - Pittsburgh PA, US
Jeffrey K. Cohen - Pittsburgh PA, US
Assignee:
Chem Image Corporation - Pittsburgh PA
International Classification:
A61B 5/00
US Classification:
600322
Abstract:
The invention relates to methods and devices for assessing one or more blood components in an animal. The present invention permits non-invasive assessment of blood components in a body structure containing blood and other tissue types by assessing multiple regions of a tissue surface for an optical characteristic of blood and separately assessing one or more optical (e. g. , Raman or NIR) characteristics of the blood component for one or more regions that exhibit the optical characteristic of blood.
Apparatus And Method For Chemical Imaging Of A Biological Sample
US Patent:
7045757, May 16, 2006
Filed:
Apr 4, 2005
Appl. No.:
11/097161
Inventors:
David Tuschel - Monroeville PA, US
John Maier - Pittsburgh PA, US
Joseph Demuth - Pittsburgh PA, US
John Maier - Pittsburgh PA, US
Joseph Demuth - Pittsburgh PA, US
Assignee:
Chemimage Corporation - Pittsburgh PA
International Classification:
H01L 27/00
US Classification:
2502081, 250226
Abstract:
In one embodiment, the disclosure relates to a method for determining illumination parameters for a stained sample, the method may include providing a stained sample and obtaining an absorption band of the sample; obtaining an emission band of the sample and determining the illumination parameters for the sample as a function of the absorption band and the emission band of the sample.
Method And Apparatus For Multiwavelength Imaging Spectrometer
US Patent:
7012695, Mar 14, 2006
Filed:
Jul 19, 2004
Appl. No.:
10/893332
Inventors:
John S. Maier - Pittsburgh PA, US
Patrick J. Treado - Pittsburgh PA, US
Chenhui Wang - Stow OH, US
Patrick J. Treado - Pittsburgh PA, US
Chenhui Wang - Stow OH, US
Assignee:
ChemImage Corporation - Pittsburgh PA
International Classification:
G01B 9/02, G02F 1/1335
US Classification:
356453, 349193
Abstract:
The disclosure generally relates to a method and apparatus for multi-wavelength imaging spectrometer. More specifically, in one embodiment, the disclosure relates to an optical filter for passing photons therethrough. The filter includes a first filter stage and a second filter stage. The first filter stage may include a first retarder element and a first liquid crystal cell. The first element may include an input face and an output face. One of the first element faces is not oriented substantially normal to the trajectory of photons passing through the filter.
Dynamic Imaging Of Biological Cells And Other Subjects
US Patent:
7564546, Jul 21, 2009
Filed:
Jun 30, 2005
Appl. No.:
10/556038
Inventors:
John S. Maier - Pittsburgh PA, US
Patrick J. Treado - Pittsburgh PA, US
David Tuschel - Monroeville PA, US
Thomas C. Voigt - Export PA, US
Patrick J. Treado - Pittsburgh PA, US
David Tuschel - Monroeville PA, US
Thomas C. Voigt - Export PA, US
Assignee:
ChemImage Corporation - Pittsburgh PA
International Classification:
G01J 3/44, G01N 21/65
US Classification:
356301
Abstract:
The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e. g. , a visible microscopic image) obtained from the field of view.
System And Method For The Electrostatic Detection And Identification Of Threat Agents
US Patent:
7471387, Dec 30, 2008
Filed:
Feb 9, 2006
Appl. No.:
11/351278
Inventors:
Patrick J. Treado - Pittsburgh PA, US
John S. Maier - Pittsburgh PA, US
David Keller - Newtown PA, US
John S. Maier - Pittsburgh PA, US
David Keller - Newtown PA, US
International Classification:
G01N 21/00, G01N 21/65
US Classification:
356301, 356 73
Abstract:
A system and method for detecting aerosol threats comprising electrostatic collection and deposition of a threat agent onto a substrate. The threat agent deposited on the substrate is illuminated with a plurality of photons to thereby produce Raman scattered photons. The Raman scattered photons are analyzed in order to identify the threat agent.
Method For Raman Computer Tomography Imaging Spectroscopy
US Patent:
2006015, Jul 20, 2006
Filed:
Jan 20, 2006
Appl. No.:
11/336588
Inventors:
John Maier - Pittsburgh PA, US
Patrick Treado - Pittsburgh PA, US
Patrick Treado - Pittsburgh PA, US
Assignee:
ChemImage Corporation - Pittsburgh PA
International Classification:
G01J 3/44, G01N 21/65
US Classification:
356301000
Abstract:
A method for measuring spatial and spectral information from a sample using computed tomography imaging spectroscopy. An area of the sample is illuminated using an illumination source having substantially monochromatic light. Raman scattered light is directed from said illuminated area of said sample onto a two dimensional grating disperser. Light output, from the two dimensional grating disperser, is directed onto a detector that detects a dispersed image. The dispersed image from the detector is applied to a processing algorithm that generates a plurality of spatially accurate, wavelength resolved images of the sample.
Invasive Chemometry
US Patent:
2013026, Oct 10, 2013
Filed:
May 31, 2013
Appl. No.:
13/907544
Inventors:
John S. Maier - Pittsburgh PA, US
International Classification:
G06F 19/10
US Classification:
702 19
Abstract:
The invention relates to methods and devices for assessing one or more components of a selected tissue in an animal. The present invention permits non-invasive assessment of tissue components in a body structure containing multiple tissue types by assessing multiple regions of the animal's body for an optical characteristic of the tissue of interest and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the tissue component for one or more regions that exhibit the optical characteristic of the tissue of interest.