Inventors:
Eric Connor - Los Gatos CA, US
Dominique Charmot - Campbell CA, US
Han-Ting Chang - Livermore CA, US
Florence Roger - Preverenges, CH
Gerrit Klaerner - San Jose CA, US
Son Hoai Nguyen - San Jose CA, US
Jonathan Mills - San Jose CA, US
Jerry M. Buysse - Los Altos CA, US
Angela Lee - San Jose CA, US
Deidre Madsen - Sunnyvale CA, US
Jun Shao - Fremont CA, US
Michael J. Cope - Berkeley CA, US
John Fordtran - Dallas TX, US
Assignee:
Ilypsa, Inc. - Thousand Oaks CA
International Classification:
C08F 26/06, C07C 211/11
US Classification:
526310, 526258, 525334, 525374, 525526, 424 7806, 424 7811, 424 7812, 424 7816, 524612, 521 36, 564511, 564512
Abstract:
Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.