DR. JOHN S. FISHER, M. D.
Radiology at Druid Rd, Clearwater, FL

2013027, Oct 17, 2013

Jun 6, 2013

13/911708

John S. Fisher - Belleair FL, US

A61F 2/02

623 2372, 523105

A hydrogel plug is placed under stress during its curing stage, in one embodiment, by application of an externally applied force. The stress may also be induced during or after the dehydration process. The direction of the externally applied force increases the length, width, depth, or radial extent of the plug. The elastic limit of the plug is exceeded when the external force is applied so that the plug substantially retains its stressed size and shape when the externally applied force is removed. When the stretched or otherwise deformed dehydrated plug is hydrated, it substantially returns to the configuration it had prior to its dehydration and prior to the application of the externally applied force.

6350244, Feb 26, 2002

Feb 21, 2000

09/507052

John S. Fisher - Belleair FL

Biopsy Sciences, LLC - Clearwater FL

A61B 1000

600562, 606116

A bioabsorbable marker is placed in soft tissue such as breast tissue near a lesion during a biopsy procedure. If tests prove the lesion to be malignant, the marker indicates the location of the lesion and the marker is removed surgically together with the lesion. If tests prove the lesion to be benign, there is no need to surgically remove the marker due to its bioabsorbability. One or more markers may be carried in an elongate, flexible marker carrier that is ensheathed within an elongate, flexible outer sheath. The flexible outer sheath is slidingly introduced into the proximal end of a biopsy needle until its distal free end protrudes from a port formed in the distal end of the biopsy needle. Retraction of the outer sheath relative to the marker carrier then exposes the marker carrier. The markers exit the marker carrier under their own inherent bias or an auxiliary bias is employed to eject them from the marker carrier.

6530940, Mar 11, 2003

Apr 18, 2001

09/837792

John S. Fisher - Belleair FL 33756

A62M 2900

606200, 606194, 604105

A balloon angioplasty apparatus includes a guide wire, a balloon catheter, and a guide catheter. The balloon catheter has slots formed in it to define a plurality of elongate members between the slots. A joint is formed at the proximal, distal, and mid-point of each elongate member. Displacing the proximal and distal joints toward one another causes the respective middle joints to displace radially outwardly, and radial inward travel of the middle joints is caused by increasing the distance between the proximal and distal joints. A mesh that captures emboli overlies the jointed members and opens and closes with them. The guide catheter is used to close the joined members and the emboli-capturing mesh at the conclusion of the angioplasty procedure. In a second embodiment, the jointed members are formed in a delivery catheter. In a third embodiment, the jointed members are formed in a guide wire.

6685727, Feb 3, 2004

Mar 27, 2003

10/249261

John S. Fisher - Belleair FL
Frederick Ahari - Tucson AZ
Lucjan J. Hronowski - Bedford MA

Bio-SEAL, LLC - Clearwater FL

A61B 1708

606213, 606214

Openings in a mammalian body made by any medical procedure or non-medical event are sealed with a bioabsorbable plug or sewn with a bioabsorbable suture. In one exemplary embodiment, the plug in dehydrated, unexpanded condition is pushed by a pushing device through the lumen of a needle until a first part of the plug is external to the opening and a second part is internal to the opening. The needle is then withdrawn while the position of the pushing device is maintained. The pushing device is then withdrawn, leaving the plug in sealing relation to the opening. The bodys moisture causes the plug to expand to complete the sealing of the opening, or the expansion may be caused by exposure to air, light, or other stimulant. The opening may be formed in soft tissue, internal organs, or hard tissue. The plug seals the flow of liquid or gaseous biological fluids.

6709408, Mar 23, 2004

Sep 23, 2002

10/065155

John S. Fisher - Belleair FL

Biopsy Sciences, LLC - Clearwater FL

A61B 1000

600570, 600571, 600562, 600576, 606160, 604 22

A dual action biopsy needle scrapes tissue of cellular thickness from a lesion during forward and rearward reciprocations of the needle along its longitudinal axis of symmetry. A first sharp edge, formed by a beveled distal end of the needle, scrapes tissue during proximal-to-distal travel of the needle. A second sharp edge is provided by a transversely disposed slot formed in the needle near the first sharp edge. The second sharp edge scrapes tissue during distal-to-proximal travel of the needle. In a first embodiment, the second sharp edge is coincident with an exterior surface of the needle. In a second embodiment, the second sharp edge is elevated with respect to the exterior surface and in a third embodiment the second sharp edge is recessed. Additional embodiments include a second slot, a channel, and a hinge for enabling pivotal movement of the second and third sharp edges.

6264672, Jul 24, 2001

Oct 25, 1999

9/426438

John S. Fisher - Belleair FL

Biopsy Sciences, LLC - Clearwater FL

A62M 2900

606200

An apparatus used in balloon angioplasty and/or stenting in a first embodiment includes a guide wire, a balloon catheter that ensleeves the guide wire, and a guide catheter that ensleeves the balloon catheter. The balloon catheter has a plurality of longitudinally-extending, circumferentially spaced apart slots formed in it to define a plurality of elongate members between the slots. A joint is formed at the proximal, distal, and mid-point of each elongate member. Displacing the respective proximal and distal joints toward one another causes the respective middle joints to displace radially outwardly, and radial inward travel of the middle joints is caused by increasing the distance between the proximal and distal joints. A bead is formed in the distal end of the guide wire and retraction of the guide wire causes the bead to abut the distal end of the balloon catheter and displace it in a distal-to-proximal direction, opening the elongate, jointed members. A mesh that captures emboli while allowing blood perfusion partially overlies the jointed members and is opened when the jointed members are opened and closed when they are closed.

7329414, Feb 12, 2008

May 3, 2002

10/063620

John S. Fisher - Belleair FL, US
Frederick Ahari - Tucson AZ, US
Lucjan J. J. Hronowski - Bedford MA, US

Biopsy Sciences, LLC - Clearwater FL

A61F 2/02, A61K 51/02

424426, 424 11, 424 125

A tissue marker formed of a biodegradable polymer having drug-delivery capabilities is combined with a sealant that encapsulates the tissue marker and which serves to help anchor the tissue marker against migration. The sealant is delivered to a site in dehydrated form and moisture inherent in tissue at the site expands the sealant. The expanded sealant is formed of a hydrogel and is therefore more compatible to the surrounding tissue than the material of the tissue marker. The sealant and the tissue marker are both bioabsorbed over time.

2012032, Dec 27, 2012

Jun 21, 2012

13/529445

John S. Fisher - Belleair FL, US
Fred Ahari - Clearwater FL, US
Christopher Jon Perry - Largo FL, US
Lucjan J.J. Hronowski - Bedford MA, US

SYNTHETECH PHARMACEUTICALS, LLC - Clearwater FL

A61K 33/00, A61K 31/17, A61K 31/16, A61K 31/155, A61K 33/06, A61P 7/02

424607, 424611, 514616, 514638, 514588

The present invention provides an aqueous composition and its use for dissolving blood clots in vivo or in clinical or research samples in vitro, said composition comprising at least one chaotropic agent, at least one chelating agent that complexes iron if the chaotropic agent does not complex iron and at least one surface-active emulsifier, the composition being buffered near pH 7.4. The process of dissolving the clot with the aqueous composition is advantageous because it is simple, inexpensive, rapid and can be applied in a variety of contexts, including basic research and clinical situations.

6872185, Mar 29, 2005

Mar 19, 2004

10/708710

John S. Fisher - Belleair FL, US

Biopsy Sciences, LLC - Clearwater FL

A61B010/00

600570, 600571, 600562, 600576, 606160, 604 22

A biopsy needle scrapes tissue of cellular thickness from a lesion during repeated proximal-to-distal thrusts of the needle along its longitudinal axis of symmetry. A first sharp edge, formed by a beveled distal end of the needle, scrapes tissue during proximal-to-distal travel of the needle. A second sharp edge is provided by a transversely disposed slot formed in the needle near the first sharp edge. The second sharp edge also scrapes tissue during proximal-to-distal travel of the needle. The second sharp edge may be coincident with an exterior surface of the needle elevated with respect to the exterior surface, or recessed with respect to the exterior surface. Another embodiment includes a hinge for enabling pivotal movement of the second sharp edge.