Inventors:
Min Yue - Belmont CA, US
David M. Liu - Los Altos CA, US
Joy Roy - San Jose CA, US
Yuh-Min Chiang - Sunnyvale CA, US
Joon Mo Yang - Redwood City CA, US
Dennis Lehto - Santa Clara CA, US
Charles S. Vann - Marietta GA, US
Nigel P. Beard - Redwood City CA, US
Ian A. Harding - San Mateo CA, US
John R. Van Camp - San Ramon CA, US
Alexander Dromaretsky - Davis CA, US
Sergey V. Ermakov - Hayward CA, US
Mark F. Oldham - Foster City CA, US
Maryam Shariati - Sunnyvale CA, US
Umberto Ulmanella - Foster City CA, US
Assignee:
Applied Biosystems, LLC - Carlsbad CA
International Classification:
G01N 21/75
US Classification:
422402, 4352884, 4352883, 4352975, 4353031, 436180, 436518
Abstract:
Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.