JOHN RUSSELL SEMLER
Pilots at Overlook Dr, Buffalo, NY

2010024, Sep 30, 2010

Mar 30, 2010

12/798093

John R. Semler - Williamsville NY, US
Kathleen H. Selover - East Concord NY, US
Bermina L. Rohde - Cheektowaga NY, US

A61B 5/00

600561

A method of determining body exit of an ingestible capsule comprising the steps of providing () an ingestible capsule () having a pressure sensor (), having () a subject ingest the capsule, recording () measurements from the pressure sensor as the capsule passes through at least an end portion of a gastrointestinal tract of the subject, transmitting () the measurements to a processor () outside of the gastrointestinal tract of the subject, identifying () an increasing pressure sequence () in the measurements between a selected start time () and a transmission end time (), comparing () the sequence to a reference (), and using the comparison to make a determination () regarding the capsule exiting the gastrointestinal tract of the subject. The increasing pressure sequence may be the longest increasing pressure sequence in the measurements. The reference may be a logarithmic regression of the measurements. The ingestible capsule may further comprise a temperature sensor () and the method may further comprising the steps of recording () measurements from the temperature sensor as the capsule passes through the end portion of the gastrointestinal tract of the subject, transmitting () the measurements to the processor, analyzing () the temperature measurements for a substantial drop () in the temperature measurements, and using the analysis of the temperature measurements to make the determination regarding the capsule exiting the gastrointestinal tract of the subject.

2009028, Nov 12, 2009

May 5, 2009

12/387609

John R. Semler - Williamsville NY, US
Paul E. Buckley - Elma NY, US
Andreas J.P.M. Smout - Utrecht, NL

A61B 5/07, A61B 5/00

600301, 600302

A computerized method of determining the slow wave of a gastrointestinal tract comprising the steps of providing an ingestible capsule () having a pressure sensor (), having a subject ingest the capsule, recording measurements from the pressure sensor as the capsule passes through the gastrointestinal tract of the subject, transmitting the measurements to a processor (), conditioning the measurements () to provide pressure data as a function of a time interval (), interpolating missing pressure data in the time interval (), filtering the pressure data as a function of a desired bandpass (), differencing the pressure data (), windowing the pressure data (), applying a sample size and an overlap between samples to segment the pressure data (), applying a Fourier transform to the segmented pressure data to provide frequency pressure data (), selecting an FFT frequency bandpass (), computing power spectrum density of the transformed pressure data for the FFT bandpass (), and plotting the transformed pressure data (), whereby a dominate pressure frequency () correlating to a slow wave of at least a portion of the gastrointestinal tract is provided.

2008028, Nov 20, 2008

Sep 6, 2007

11/899540

John R. Semler - Williamsville NY, US
Braden Kuo - Newton MA, US

A61B 5/00

600593, 128898

A method of evaluating gastroparesis comprising the steps of providing an ingestible capsule having a pH sensor and a pressure sensor, having a subject ingest the capsule, recording pH measurements from the pH sensor as a function of time as the capsule moves through at least a portion of the gastrointestinal tract of the subject, recording pressure measurements from the pressure sensor as a function of time as the capsule moves through at least a portion of the gastrointestinal tract of the subject, determining the capsule's location at a first position in the gastrointestinal tract, deriving a pressure pattern as a function of time and the pressure measurements, providing a reference pressure pattern, and analyzing the subject's pressure pattern relative to the reference pressure pattern to evaluate the subject with respect to gastroparesis. The location may be the junction between the stomach and the small bowel of the subject. The pressure pattern may be the number of contractions relative to a baseline over a given time interval or area under the curve of pressure measurements over a given time interval.

2008006, Mar 13, 2008

Sep 6, 2007

11/899544

John R. Semler - Williamsville NY, US
Braden Kuo - Newton MA, US

A61B 5/03

600309

A method of determining the location of an ingested capsule comprising the steps of providing an ingestible capsule having a pH sensor and a pressure sensor, having a subject ingest the capsule, recording pH measurements from the pH sensor as a function of time as the capsule moves through at least a portion of the gastrointestinal tract of the subject, recording pressure measurements from the pressure sensor as a function of time as the capsule moves through at least a portion of the gastrointestinal tract of the subject, deriving a pressure pattern as a function of time and the pressure measurements, providing a reference pH, analyzing the pH variations for the subject relative to the reference pH to determine the capsule's location at a first position, providing a reference pressure pattern, and analyzing the pressure pattern variations for the subject relative to the pressure pattern reference to determine the capsule's location at a second position. The pressure pattern may be frequency of contractions relative to a baseline over a given time interval or motility index. The method may further comprise the steps of analyzing the pressure pattern variations for the subject relative to the pressure pattern reference in determining the capsule's location at the first position and/or analyzing the pH variations for the subject relative to the pH reference in determining the capsule's location at the second position.

2009031, Dec 17, 2009

Jun 11, 2009

12/456093

Laura A. Matott - East Aurora NY, US
John R. Semler - Williamsville NY, US
Mark Scott - London, GB

A61B 6/12

600424

A method of determining the location of an ingested capsule comprising the steps of providing an ingestible capsule () having a shell () and a flexible fluid retaining sleeve () affixed to the sleeve and defining a chamber () between the shell and the sleeve, the fluid retaining sleeve having a fill port (), providing a radioactive material () contained in a filling device () having an output port () adapted to engage the fill port of the sleeve, engaging the output port of the filling device with the fill port of the sleeve, moving the radioactive material through the output port and into the chamber of the sleeve through the sleeve fill port, sealing the fill port to provide a radio-labeled ingestible capsule, having a subject ingest the radio-labeled capsule, and screening the subject by gamma imagining to determine location of the radio-labeled capsule within the subject.

6257015, Jul 10, 2001

Jan 19, 2000

9/488408

Samuel A. Incorvia - North Tonawanda NY
Peter R. Millen - Perry NY
John R. Semler - Williamsville NY

Multisorb Technologies, Inc. - Buffalo NY

F25B 4304

62475

An adsorbent unit for mounting relative to a U-bend pipe of a refrigerant accumulator having spaced pipes and a return bend including a porous container, adsorbent in the container, first and second end portions on the container, first and second bands on the first end portion for placement about the spaced pipes, and a mounting tab at the second end portion for mounting onto a filter housing on the return bend.

5066633, Nov 19, 1991

Feb 9, 1990

7/478259

Tomoo Shibata - Amherst NY
John Semler - Buffalo NY
George Gaesser - North Tonawanda NY

Graphic Controls Corporation - Buffalo NY

B41M 530

503209

A heat sensitive coating has a colorless or light colored leuco dye precursor, preferably having a five-membered spirol lactone ring at one end of the molecule, and a tertiary amino group at another end of the molecule, and a developer. Sensitizers which increase the heat sensitivity of these dye precursors, and compositions of sensitized dye/developer systems are disclosed. The sensitizers are. gamma. -substituted lactones, 3-naphthylmethylidenephthalide, and derivatives of benzalphthalide.

6205809, Mar 27, 2001

Jan 19, 2000

9/487500

Samuel A. Incorvia - North Tonawanda NY
John R. Semler - Williamsville NY

Multisorb Technologies, Inc. - Buffalo NY

F25B43/00

62474

An adsorbent unit including a porous container, adsorbent in the container, at least one tab extending outwardly from the container, side edges on the tab, and concave indentations in the side edges. The tab can have an aperture therein for mounting the tab on the filter body of a return bend of an accumulator. Another embodiment of the adsorbent unit can include two tabs extending outwardly from the opposite ends of the container, rigid outer ends on the tabs, and concave indentations in the sides of the tabs between the outer ends of the tabs and the adsorbent container. In use, the concave indentations of the various tabs receive the spaced pipes of a return bend pipe utilized in a refrigerant accumulator.

2007012, Jun 7, 2007

Dec 6, 2005

11/294978

David D'Andrea - Getzville NY, US
Laura Negron - West Seneca NY, US
John Semler - Williamsville NY, US

A61M 31/00

604503000

An improved capsule () for sensing a contractual force within a mammalian tract, comprising a shell (), a flexible sleeve () affixed to the shell and defining a chamber () between the shell and the sleeve, and a pressure sensor () operatively arranged to sense pressure within the chamber, whereby a contraction force on the outside of the sleeve produces a corresponding pressure change within the chamber. The chamber may contain a fluid () and the fluid may be mineral oil.

2012020, Aug 16, 2012

Dec 14, 2011

13/326045

John R. Semler - Williamsville NY, US

THE SMART PILL CORPORATION - Buffalo NY

A61B 5/145, A61B 5/03

600301

A method of determining the location of an ingested capsule comprising the steps of providing an ingestible capsule having a pH sensor and a pressure sensor, having a subject ingest the capsule, recording pH measurements from the pH sensor as a function of time as the capsule moves through at least a portion of the gastrointestinal tract of the subject, recording pressure measurements from the pressure sensor as a function of time as the capsule moves through at least a portion of the gastrointestinal tract of the subject, deriving a frequency of contractions pressure pattern as a function of time and the pressure measurements, and identifying an appreciable variation in the frequency pressure pattern in substantially the same time period as an appreciable variation in the pH to determine the capsule's location at a first position in the gastrointestinal tract of the subject.