JOHN RICHARD HOYER
Medical Practice in Penn Wynne, PA
License number
Pennsylvania MD030217E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Penn Wynne, PA 19096
Personal information
See more information about JOHN RICHARD HOYER at radaris.comName
Address
Phone
1001 Felix Ct, Reading, PA 19605
369 Ramsey Rd, Yardley, PA 19067
443 Riviera Dr, Blandon, PA 19510
526 Joyce Rd, Camp Hill, PA 17011
605 Crescent Ave, Reading, PA 19605
Professional information
Biological Regulation Of Mineralization
US Patent:
5304496, Apr 19, 1994
Filed:
Jun 10, 1991
Appl. No.:
7/712476
Inventors:
John Hoyer - Wynnewood PA
John Sinclair - Cambridgeshire, GB
Leszek Borysiewicz - Cambridgeshire, GB
John Sinclair - Cambridgeshire, GB
Leszek Borysiewicz - Cambridgeshire, GB
Assignee:
Children's Hospital of Philadelphia - Philadelphia PA
International Classification:
G01N 3353, A61K 3702, C07K 710, C07K 708
US Classification:
436 86
Abstract:
An aspartic acid rich protein isolated from human urine, as well as proteins having substantial homology thereto and active portions of the foregoing are effective modulators of mineralization in mammals. These proteins and peptides are useful as therapeutic agents, such as in the treatment of kidney stone disease. Hybridoma cell lines capable of producing monoclonal antibodies to these proteins and peptides and monoclonal antibodies produced by these hybridomas are disclosed. These monoclonal antibodies are also useful as therapeutic agents, such as in the treatment of osteoporosis, and further have utility as diagnostic agents. Other uses are also described.