Inventors:
Shengying Li - Ann Arbor MI, US
David H. Sherman - Ann Arbor MI, US
John Montgomery - Ann Arbor MI, US
Mani R. Chaulagain - Evansville IN, US
Allison R. Knauff - Ann Arbor MI, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI
International Classification:
A61K 31/704, C12P 19/44, C12P 19/56, C12P 33/20, C12P 19/62, C07H 15/203, C07H 15/24, C07H 17/08, C07J 41/00, C07H 15/20, C07C 217/52, A61K 31/7048, A61K 31/7034, A61K 31/13, A61K 31/133, A61P 31/04, A61K 31/7028, C07H 15/10, C12N 9/02
US Classification:
514 26, 435189, 435 74, 435 78, 435 53, 435 76, 536 168, 536 71, 536 5, 564454, 564457, 514 28, 514 34, 514 25, 514659, 514660
Abstract:
The present invention provides regio- and stereoselective oxidation of unactivated C—H bonds using an engineered mutant cytochrome P450 monooxygenase and an engineered substrate.