JOHN Q TROJANOWSKI
Medical Practice in Philadelphia, PA
License number
Pennsylvania MD023202E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Philadelphia, PA 19104
Personal information
See more information about JOHN Q TROJANOWSKI at radaris.comName
Address
Phone
323 Wallace St, Erie, PA 16507
2005 Pine St, Philadelphia, PA 19103
1985 Lincoln Way STE 23, White Oak, PA 15131
1217 Macon Ave, Pittsburgh, PA 15218
3400 Spruce St, Philadelphia, PA 19104
Professional information
John Trojanowski, Philadelphia PA
Work:
Hospital of the University of PA
3400 Spruce St, Philadelphia, PA 19175 University of Pennsylvania
3600 Spruce St, Philadelphia, PA 19104
3400 Spruce St, Philadelphia, PA 19175 University of Pennsylvania
3600 Spruce St, Philadelphia, PA 19104
Diagnostic Methods For Alzheimers Disease By Detection Of Multiple Mrnas
US Patent:
6358681, Mar 19, 2002
Filed:
Oct 30, 1998
Appl. No.:
09/183636
Inventors:
Stephen Ginsberg - Philadelphia PA
John Q. Trojanowski - Philadelphia PA
Virginia M.-Y. Lee - Philadelphia PA
James Eberwine - Philadelphia PA
John Q. Trojanowski - Philadelphia PA
Virginia M.-Y. Lee - Philadelphia PA
James Eberwine - Philadelphia PA
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12Q 168
US Classification:
435 6, 435 911, 435 912
Abstract:
Methods of detecting RNA in brain tissue of patients with Alzheimers disease are provided. Methods of diagnosing Alzheimers disease by detection of these RNAs are also provided.
Methods And Compositions For Determining Lipid Peroxidation Levels In Oxidant Stress Syndromes And Diseases
US Patent:
6727075, Apr 27, 2004
Filed:
May 31, 2001
Appl. No.:
09/870762
Inventors:
Garret A. Fitzgerald - Wayne PA
Joshua Rokach - Satellite Beach FL
Domenico Pratico - Philadelphia PA
John Q. Trojanowski - Philadelphia PA
Joshua Rokach - Satellite Beach FL
Domenico Pratico - Philadelphia PA
John Q. Trojanowski - Philadelphia PA
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
Florida Institute of Technology - Melbourne FL
Florida Institute of Technology - Melbourne FL
International Classification:
C12Q 126
US Classification:
435 25, 435 71
Abstract:
The invention includes methods useful for the diagnosis of Alzheimers disease and the evaluation of enhanced levels of lipid peroxidation in a mammal. The methods utilize isoprostanes as sensitive and stable molecular markers for lipid peroxidation in a mammal. Methods of identifying compounds useful for the treatment of Alzheimers disease or for reducing levels of lipid peroxidation in a mammal are also included. The invention also includes kits useful for the diagnosis of Alzheimers disease and for the evaluation of levels of lipid peroxidation in a mammal.
Method Of Screening For Alzheimer's Disease Or Disease Associated With The Accumulation Of Paired Helical Filaments
US Patent:
5733734, Mar 31, 1998
Filed:
Oct 29, 1993
Appl. No.:
8/145827
Inventors:
John Q. Trojanowski - Philadelphia PA
Virginia M-Y. Lee - Philadelphia PA
Virginia M-Y. Lee - Philadelphia PA
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
G01N 3353, C07K 1618
US Classification:
435 71
Abstract:
Substantially purified antibodies, including substantially purified monoclonal antibodies, which are specifically reactive with. tau. that has an abnormally phosphorylated serine in the sequence LysSerProVal SEQ ID NO:3 are disclosed. Methods of screening persons for diseases associated with pair helical filaments, including Alzheimer's disease, by detection of. tau. that has an abnormally phosphorylated serine in the sequence LysSerProVal SEQ ID NO:3 in test samples taken from such persons and test kits useful to perform such methods are disclosed.
Transgenic Animal Expressing Alpha-Synuclein And Uses Thereof
US Patent:
2003021, Nov 20, 2003
Filed:
May 16, 2002
Appl. No.:
10/150043
Inventors:
Benoit Giasson - Lansdowne PA, US
John Trojanowski - Philadelphia PA, US
Virginia Lee - Philadelphia PA, US
John Trojanowski - Philadelphia PA, US
Virginia Lee - Philadelphia PA, US
International Classification:
A01K067/00
US Classification:
800/003000, 800/008000
Abstract:
The present invention relates to transgenic animals expressing A53T -Syn protein which are models for neurodegenerative disease progression. These animals may be used for screening candidate drug compounds effective against neurodegenerative diseases and other diseases involving -synucleinopathy.
Diagnostic Methods For Alzheimer's Disease By Detection Of Multiple Mrnas
US Patent:
2002010, Aug 1, 2002
Filed:
Jan 16, 2002
Appl. No.:
10/050229
Inventors:
Stephen Ginsberg - Philadelphia PA, US
John Trojanowski - Philadelphia PA, US
Virginia Lee - Philadelphia PA, US
James Eberwine - Philadelphia PA, US
John Trojanowski - Philadelphia PA, US
Virginia Lee - Philadelphia PA, US
James Eberwine - Philadelphia PA, US
International Classification:
C12Q001/68, C12P019/34
US Classification:
435/006000, 435/091200
Abstract:
Methods of detecting RNA in brain tissue of patients with Alzheimer's disease are provided. Methods of diagnosing Alzheimer's disease by detection of these RNAs are also provided.
Tau Acetylation In The Pathogenesis Of Alzheimers Disease And Other Related Tauopathies
US Patent:
2013025, Sep 26, 2013
Filed:
Mar 13, 2013
Appl. No.:
13/799842
Inventors:
Todd J. Cohen - Philadelphia PA, US
John Q. Trojanowski - Philadelphia PA, US
John Q. Trojanowski - Philadelphia PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12Q 1/48
US Classification:
4241581, 435 75, 435 71, 435 74, 5303891, 536 231, 514 177, 514 44 R
Abstract:
The present invention relates to biomarkers and diagnostic methods for Alzheimer's disease and other neurodegenerative disorders. The invention also provides compositions for detecting the biomarker as well as compositions and methods useful for treating Alzheimer's disease and other neurodegenerative disorders.
Cycloalkyl-Dione Derivatives And Methods Of Their Use
US Patent:
8530520, Sep 10, 2013
Filed:
Jun 6, 2012
Appl. No.:
13/489745
Inventors:
Onur Atasoylu - Izmir, TR
Carlo Ballatore - Philadelphia PA, US
Kurt R. Brunden - Media PA, US
Longchuan Huang - Philadelphia PA, US
Donna M. Huryn - Allentown NJ, US
Michael James - Philadelphia PA, US
Francesco Piscitelli - Strongoli Marina, IT
James Soper - Cambridge MA, US
John Q. Trojanowski - Philadelphia PA, US
Carlo Ballatore - Philadelphia PA, US
Kurt R. Brunden - Media PA, US
Longchuan Huang - Philadelphia PA, US
Donna M. Huryn - Allentown NJ, US
Michael James - Philadelphia PA, US
Francesco Piscitelli - Strongoli Marina, IT
James Soper - Cambridge MA, US
John Q. Trojanowski - Philadelphia PA, US
Assignee:
The Trustees Of The University Of Pennsylvania - Philadelphia PA
International Classification:
A61K 31/18
US Classification:
514604
Abstract:
The present invention is directed to carboxylic acid-containing pharmaceutical compounds where the carboxylic acid moieties have been substituted with cycloalkyl-dione derivatives, as well as tautomers and pharmaceutically acceptable salt forms thereof. These bioisosteric replacements improve the compound's ability to effectively cross the blood brain barrier and result in improved pharmacokinetic, toxicological, and/or safety profiles.
Novel Tetrahydronaphalene Antagonists To The Thromboxane A2 (Tp) Receptor
US Patent:
2013019, Jul 25, 2013
Filed:
Jul 27, 2011
Appl. No.:
13/812793
Inventors:
John Q. Trojanowski - Philadelphia PA, US
Virginia M.Y. Lee - Philadelphia PA, US
Kurt R. Brunden - Medla PA, US
Amos B. Smith - Merion PA, US
Donna M. Huryn - Allentown NJ, US
Carlo Ballatore - Philadelphia PA, US
Anne-Marie Hogan - Mount Merrion, IE
Francesco Piscitelli - Marina dl Strongoii, IT
Virginia M.Y. Lee - Philadelphia PA, US
Kurt R. Brunden - Medla PA, US
Amos B. Smith - Merion PA, US
Donna M. Huryn - Allentown NJ, US
Carlo Ballatore - Philadelphia PA, US
Anne-Marie Hogan - Mount Merrion, IE
Francesco Piscitelli - Marina dl Strongoii, IT
Assignee:
The Trustees of the University of Pennsylvania - Philadephia PA
International Classification:
C07C 311/20, C07D 317/28, A61K 31/196, A61K 45/06, A61K 31/18, A61K 31/41, A61K 31/357, C07D 257/04, A61K 31/216
US Classification:
514381, 560 10, 562430, 564 91, 548252, 549491, 514510, 514562, 514604, 514467
Abstract:
The present invention relates to TP receptor antagonists, which have the ability to bind to TP receptor and optionally cross the blood brain barrier. The invention also provides compositions and methods for treating a disorder wherein activation of TP receptor is detrimental.
Cell-Based Models Of Neurodegenerative Disease
US Patent:
2013033, Dec 19, 2013
Filed:
Nov 4, 2011
Appl. No.:
13/882674
Inventors:
Kurt R. Brunden - Media PA, US
Virginia M.Y. Lee - Philadelphia PA, US
John Q. Trojanowski - Philadelphia PA, US
Kelvin C. Luk - Philadelphia PA, US
Jing Guo - Philadelphia PA, US
Virginia M.Y. Lee - Philadelphia PA, US
John Q. Trojanowski - Philadelphia PA, US
Kelvin C. Luk - Philadelphia PA, US
Jing Guo - Philadelphia PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
G01N 33/68, G01N 33/50
US Classification:
435 613, 435325, 435 29
Abstract:
The present invention relates to a cell-based model useful for identifying molecules that modify intracellular pathways of α-synuclein and tau aggregation and degradation.