Inventors:
John P. Delaney - Minneapolis MN, US
Assignee:
Anhese LLC - Minneapolis MN
International Classification:
A61K 9/00, A61K 31/336, A61K 31/205, A61K 31/365, A61K 31/439, A61K 9/14
US Classification:
424423, 514475, 514563, 514473, 514291, 424489
Abstract:
A method for inhibiting formation of adhesions following abdominal surgery which involves application of an anti-static fatty acid ethoxylated amide (Cocamide DEA) in a matrix that is placed in the peritoneal cavity at the conclusion of an abdominal surgery and which releases this anti-adhesive chemical over a predetermined time in a range from about five to seven days. Tests conducted on laboratory rats established that the method reduced the incidences of adhesions from 100 percent (100%) in a test model to near zero percent (0%) in the treated animals. In an alternative embodiment, Andrographalide was delivered through a drug pump with similar results. In still another embodiment, an effective amount of Rapamune was delivered, via a pump, into the abdominal cavity, again with similar results.