Inventors:
John A. Oates - Nashville TN, US
Ned A. Porter - Franklin TN, US
Olivier Boutaud - Nashville TN, US
Assignee:
Vanderbilt University - Nashville TN
International Classification:
A01N 43/58, A01N 43/54, A01N 43/40, A01N 43/42, A61K 31/50, A61K 31/435, A61K 31/44, C07D 239/42, C07D 401/04
US Classification:
514247, 514256, 514277, 514279
Abstract:
Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.