Inventors:
John Kheir - Boston MA, US
Francis X. McGowan - Charleston SC, US
Andrew Loxley - Bethlehem PA, US
Robert Lee - Bethlehem PA, US
Assignee:
Children's Medical Center Corporation - Boston MA
International Classification:
A61K 9/50, A61M 5/19, A61B 5/029, A61M 16/00, A61K 33/00, A01N 1/02
US Classification:
424400, 424613, 435 11, 435 2, 600526, 12820024
Abstract:
Compressible and concentrated suspensions containing gas-filled microbubbles, uses thereof for delivering gas into a subject in need thereof, and systems for delivering the compressible suspensions. The gas-filled microbubbles each comprise a gas core surrounded by a lipid membrane, which includes (a) one or more lipids, such as 1,2-disteroyl-sn-glycero-3-phosphocholine (DSPC) or dipalmitoylphosphatidylcholine (DPPC), and (b) one or more stabilizing detergents, such as poloxamer 188, Pluronic F108, Pluronic F127, polyoxyethylene (100) stearyl ether, cholesterol, gelatin, polyvinylpyrrolidone (PVP), and sodium deoxycholate (NaDoc).