Assignee:
Cornell Research Foundation, Inc. - Ithaca NY
International Classification:
A61K 39385
US Classification:
4241931, 4242651, 4242691, 514 2
Abstract:
The present invention relates to methods of treating inflammatory diseases, inhibiting production of adhesion molecules on endothelial cells, inhibiting production of nitric oxide synthase by macrophages, inhibiting production of tissue factor by endothelial cells, reversing the inhibitory effects of lipophosphoglycan on endothelial cells or macrophages, and targeting a material to endothelial cells, fibroblasts, or monocytes, by administering lipophosphoglycan or lipophosphoglycan analog. Also disclosed is an isolated DNA molecule suitable for connection to a gene capable of transcription where lipophophoglycan or lipophosphoglycan analogues bind to the DNA molecule and antagonizes transcription of the gene.