JOHN MANSFIELD HALLENBECK, MD
Hospitals at Franklin St, Kensington, MD
License number
Maryland DOO41217
Category
Hospitals
Type
Medicare Defined Swing Bed Unit
Address
Address
4113 Franklin St, Kensington, MD 20895
Phone
(301) 933-0656
(301) 402-2336 (Fax)
(301) 402-2769 (Fax)
(301) 402-2336 (Fax)
(301) 402-2769 (Fax)
Professional information
Increased Resistance To Stroke By Developing Immunologic Tolerance To Myelin Or Components Thereof
US Patent:
6068844, May 30, 2000
Filed:
Dec 19, 1997
Appl. No.:
8/994293
Inventors:
Kyra J. Becker - Seattle WA
John M. Hallenbeck - Kensington MD
Richard M. McCarron - Kensington MD
John M. Hallenbeck - Kensington MD
Richard M. McCarron - Kensington MD
Assignee:
The United States of America as represented by the Department of Health
and Human Services - Washington DC
and Human Services - Washington DC
International Classification:
A61K 3804, A61K 3817, C07K 100
US Classification:
4241841
Abstract:
The present invention relates to a method of inducing oral tolerance to ischemic injury which has the objective of minimizing the severity and size of injured regions in the brain that arise as a result of ischemia. The method responds rapidly to the onset of infarction, with treatment that is short in duration. The procedure is specifically focused on the injured area of the infarct by virtue of being targeted immunologically to the ischemic site. The method therefore avoids the possibility of inducing systemic side effects affecting other organs of the patient. The present invention involves administering myelin or a component thereof such as myelin basic protein or proteolipid protein to a subject either orally or by inhalation. The amount administered and the duration of the treatment are effective to minimize the size and severity of the infarct in the brain of the subject. The method is intended for acute conditions related either to an actual recent cerebral ischemic event or to a potential ischemic event that might arise as a result of medical or surgical treatment planned for the subject.
Methods For Preventing Strokes By Inducing Tolerance To E-Selectin
US Patent:
7261896, Aug 28, 2007
Filed:
May 23, 2001
Appl. No.:
10/296423
Inventors:
John M. Hallenbeck - Kensington MD, US
Hidetaka Takeda - Rockville MD, US
Maria Spatz - Bethesda MD, US
Hidetaka Takeda - Rockville MD, US
Maria Spatz - Bethesda MD, US
Assignee:
United States of America as represented by the Secretary of the Department of Health and Human Services National Institutes of Health - Washington DC
International Classification:
A61K 39/00, A61K 38/00
US Classification:
4241851, 514 8
Abstract:
The present invention provides a method for reducing stroke-related tissue damage by treating a mammal with E-selectin. Preferably, this treatment induces E-selectin tolerance in the mammal. Another aspect of the invention is a method for inducing E-selectin tolerance in a mammal through intranasal administration of E-selectin, preferably including booster administrations. The present methods are especially adapted for use in patients at increased risk of stroke or who may become at increased risk of stroke.
Methods For Preventing Strokes By Inducing Tolerance To E-Selectin
US Patent:
2007025, Nov 1, 2007
Filed:
Jun 19, 2007
Appl. No.:
11/820326
Inventors:
John Hallenbeck - Kensington MD, US
Hidetaka Takeda - Rockville MD, US
Maria Spatz - Bethesda MD, US
Hidetaka Takeda - Rockville MD, US
Maria Spatz - Bethesda MD, US
International Classification:
A61K 39/39, A61K 38/00, A61P 1/04, A61P 9/14
US Classification:
424194100, 514054000, 514008000
Abstract:
The present invention provides a method for reducing stroke-related tissue damage by treating a mammal with E-selectin. Preferably, this treatment induces E-selectin tolerance in the mammal. Another aspect of the invention is a method for inducing E-selectin tolerance in a mammal through intranasal administration of E-selectin, preferably including booster administrations. The present methods are especially adapted for use in patients at increased risk of stroke or who may become at increased risk of stroke.
Treatment Of Inflammation, Demyelination And Neuronal/Axonal Loss
US Patent:
2010020, Aug 12, 2010
Filed:
Oct 9, 2007
Appl. No.:
12/444854
Inventors:
John M. Hallenbeck - Kensington MD, US
Hideaki Wakita - Rockville MD, US
Hideaki Wakita - Rockville MD, US
Assignee:
GOVERNMENT OF THE UNITED STATES OF AMERICAS AS REP - ROCKVILLE MD
International Classification:
A61K 38/17, A61P 9/10, A61P 29/00, A61P 37/00
US Classification:
514 12
Abstract:
The invention relates to compositions and methods for treating or preventing inflammation in a mammal comprising mucosal administration of an effective amount of an E-selectin polypeptide. Such compositions and methods are useful for treating or preventing a variety of conditions and diseases, including, for example, stroke, vascular dementia and autoimmune or inflammatory demyelinating diseases such as multiple sclerosis.
E-Selectin Compositions And Use Thereof For Inducing E-Selectin Tolerance
US Patent:
2011005, Mar 3, 2011
Filed:
Aug 18, 2010
Appl. No.:
12/859048
Inventors:
JOHN M. HALLENBECK - KENSINGTON MD, US
HIDEAKI WAKITA - OKAZAKI CITY, JP
HIDEAKI WAKITA - OKAZAKI CITY, JP
International Classification:
A61K 38/18, C07K 14/42, C07K 14/485, C07K 14/705, C07K 14/00, A61K 38/16, C07H 21/00, C12N 15/63
US Classification:
514 96, 530396, 530399, 530386, 530350, 514 11, 536 235, 536 236, 514 175, 4353201
Abstract:
The invention relates to compositions and methods for treating or preventing vascular dementia in a mammal comprising mucosal administration of an amount of E-selectin polypeptide sufficient to induce bystander immune tolerance in the mammal. Another aspect of the invention relates to compositions useful for treating or preventing vascular dementia.
Treatment And Prevention Of Vascular Dementia
US Patent:
7897575, Mar 1, 2011
Filed:
Feb 28, 2008
Appl. No.:
12/072914
Inventors:
John M. Hallenbeck - Kensington MD, US
Hideaki Wakita - Okazaki, JP
Hideaki Wakita - Okazaki, JP
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 38/17
US Classification:
514 175, 514 191, 514957, 514958
Abstract:
The invention relates to compositions and methods for treating or preventing vascular dementia in a mammal comprising mucosal administration of an amount of E-selectin polypeptide sufficient to induce bystander immune tolerance in the mammal. Another aspect of the invention relates to compositions useful for treating or preventing vascular dementia.