Inventors:
John Routes - Centennial CO, US
International Classification:
C12Q001/70, C07H021/02, C12N007/00, C12N015/861
US Classification:
435/005000, 435/069300, 435/235100, 435/456000, 435/325000, 530/350000, 536/023720
Abstract:
Recombinant nucleic acid molecules encoding a mutated Group C adenoviral E1A protein and an antigen are disclosed, as well as mutated E1A-antigen fusion proteins produced by such constructs, and compositions comprising such fusion proteins and individual proteins produced by the recombinant constructs. Also included are modified adenoviral vectors and therapeutic uses for the nucleic acids, proteins, compositions, and viral vectors of the invention.