John Loring Carpenter, JR
Accountancy at Yates Ct, Littleton, CO
License number
Colorado 20882
Issued Date
Mar 28, 2001
Renew Date
Dec 1, 2015
Expiration Date
Nov 30, 2017
Type
Certified Public Accountant
Address
Address
6773 S Yates Ct, Littleton, CO 80128
Professional information
Supercritical Fluid-Assisted Nebulization And Bubble Drying
US Patent:
6630121, Oct 7, 2003
Filed:
Jun 9, 2000
Appl. No.:
09/591213
Inventors:
Robert E. Sievers - Boulder CO
Scott P. Sellers - Burlingame CA
John F. Carpenter - Littleton CO
Scott P. Sellers - Burlingame CA
John F. Carpenter - Littleton CO
Assignee:
The Regents of the University of Colorado - Boulder CO
International Classification:
A61K 5100
US Classification:
424 113, 424 9322, 424 935, 424400, 424491, 424497
Abstract:
A method of making fine dry particles of substances is provided by forming a composition comprising a substance of interest and a supercritical or near critical fluid; rapidly reducing the pressure on said composition, whereby droplets are formed; and passing said droplets through a flow of heated gas. The process does not require any organic solvent.
High Pressure Refolding Of Protein Aggregates And Inclusion Bodies
US Patent:
7767795, Aug 3, 2010
Filed:
Jan 27, 2006
Appl. No.:
11/341013
Inventors:
Theodore W. Randolph - Niwot CO, US
John F. Carpenter - Littleton CO, US
Richard St. John - San Francisco CA, US
John F. Carpenter - Littleton CO, US
Richard St. John - San Francisco CA, US
Assignee:
BaroFold Inc. - Aurora CO
International Classification:
C07K 14/00, C12N 9/00
US Classification:
530427, 435183
Abstract:
The present disclosure provides an effective method for the refolding of denatured proteins in solution so that properly folded, biologically active protein in solution is recovered in high yield. The refolding takes place at pressures between about 0. 25 kbar to about 3. 5 kbar, advantageously at about 1. 5 kbar to about 3 kbar. Typically a chaotropic agent is present at a concentration which is not effective for denaturing protein at atmospheric pressure, and optionally, oxidation-reduction reagents can be incorporated in the refolding solution so that native intramolecular disulfide bonds can be formed where that is desired. The method is applicable to substantially all proteins, especially after solubilization and/or denaturation of insoluble protein aggregates, inclusion bodies, or abnormal oligomeric (soluble) aggregates.
High-Pressure Refolding Of Proteins In The Presence Of Binding Partners
US Patent:
2008024, Oct 9, 2008
Filed:
Apr 7, 2008
Appl. No.:
12/099009
Inventors:
Matthew B. SEEFELDT - Boulder CO, US
Lyndal K. HESTERBERG - Boulder CO, US
Theodore W. RANDOLPH - Niwot CO, US
John F. CARPENTER - Littleton CO, US
Lyndal K. HESTERBERG - Boulder CO, US
Theodore W. RANDOLPH - Niwot CO, US
John F. CARPENTER - Littleton CO, US
International Classification:
C07K 1/00, C12N 9/00
US Classification:
530402, 435183
Abstract:
Methods for producing biologically active protein from aggregated and/or denatured proteins which comprise subjecting the protein to high hydrostatic pressure in the presence of a ligand or specific binding agent are disclosed. The ligand can be a macromolecule, such as another protein, a nucleic acid, or other macromolecules, or the ligand can be a small organic molecule.
Hydroxyethyl Starch-Containing Polypeptide Compositions
US Patent:
2009018, Jul 23, 2009
Filed:
Aug 19, 2008
Appl. No.:
12/193987
Inventors:
Nicholas W. Warne - Andover MA, US
Rebecca L. Koval - Billerica MA, US
John Carpenter - Littleton CO, US
Theodore W. Randolph - Longmont CO, US
Suchart Chongpraset - Bangkok, TH
Rebecca L. Koval - Billerica MA, US
John Carpenter - Littleton CO, US
Theodore W. Randolph - Longmont CO, US
Suchart Chongpraset - Bangkok, TH
International Classification:
A61K 38/20, A61P 1/00, A61P 35/00
US Classification:
424 852
Abstract:
The invention provides compositions containing hydroxyethyl starch and polypeptides, including therapeutic polypeptides such as interleukin-11, that provide for enhanced stability of the polypeptide following storage at room temperature or elevated temperatures.
Spray Freeze Dry Of Compositions For Intranasal Administration
US Patent:
2004004, Mar 4, 2004
Filed:
Apr 10, 2003
Appl. No.:
10/412652
Inventors:
Vu Truong-Le - Campbell CA, US
Binh Pham - Mountain View CA, US
John Carpenter - Littleton CO, US
Robert Seid - Chapel Hill NC, US
Theodore Randolph - Niwot CO, US
Binh Pham - Mountain View CA, US
John Carpenter - Littleton CO, US
Robert Seid - Chapel Hill NC, US
Theodore Randolph - Niwot CO, US
International Classification:
A61L009/04, A61K009/14, A61K031/715, A61K039/395, A61K039/12, A61K039/155, A61K039/215, A61K009/127
US Classification:
424/046000, 424/204100, 424/211100, 424/221100, 514/053000, 514/061000, 264/005000, 514/044000, 424/130100, 424/450000
Abstract:
This invention provides methods and compositions to preserve bioactive materials, such as peptides, nucleic acids, viruses, bacteria, cells, or liposomes, in freeze dried particles suitable for intranasal administration. Methods provide spray freeze drying of formulations to form stable freeze dried particles for intranasal administration.
Hydroxyethyl Starch-Containing Polypeptide Compositions
US Patent:
2012013, May 31, 2012
Filed:
Feb 2, 2012
Appl. No.:
13/364696
Inventors:
Nicholas W. WARNE - Andover MA, US
Rebecca L. Koval - Billerica MA, US
John Carpenter - Littleton CO, US
Theodore W. Randolph - Niwot CO, US
Suchart Chongpraset - Bangkok, TH
Rebecca L. Koval - Billerica MA, US
John Carpenter - Littleton CO, US
Theodore W. Randolph - Niwot CO, US
Suchart Chongpraset - Bangkok, TH
Assignee:
The Regent of the University of Colorado - Boulder CO
Wyeth - Madison NJ
Wyeth - Madison NJ
International Classification:
A61K 38/20, A61P 7/00, A61P 37/04, A61P 29/00, A61P 1/00
US Classification:
424 852
Abstract:
The invention provides compositions containing hydroxyethyl starch and polypeptides, including therapeutic polypeptides such as interleukin-11, that provide for enhanced stability of the polypeptide following storage at room temperature or elevated temperatures.
Hydrophobic Compositions Containing Reconstitution Enhancer
US Patent:
2009029, Dec 3, 2009
Filed:
Aug 12, 2009
Appl. No.:
12/539637
Inventors:
Marc Besman - Seattle WA, US
John Carpenter - Littleton CO, US
Mark Manning - Loveland CO, US
Lotte McNamara - Seattle WA, US
Rajiv Nayar - Hercules CA, US
John Carpenter - Littleton CO, US
Mark Manning - Loveland CO, US
Lotte McNamara - Seattle WA, US
Rajiv Nayar - Hercules CA, US
Assignee:
NOVARTIS AG - Basel
International Classification:
A61K 38/02, A61K 31/337, A61K 31/4375, A61P 43/00
US Classification:
514 2, 514449, 514283
Abstract:
Disclosed are compositions comprising a hydrophobic active agent, a polymer and a reconstitution enhancing agent. Reconstitution of the lyophilized form of the compositions takes less time than in the absence of the enhancing agent.
Temperature Sensitive Gel For Sustained Delivery Of Protein Drugs
US Patent:
5861174, Jan 19, 1999
Filed:
Jul 12, 1996
Appl. No.:
8/679199
Inventors:
Lewis P. Stratton - Greenville SC
John F. Carpenter - Littleton CO
Mark C. Manning - Fort Collins CO
John F. Carpenter - Littleton CO
Mark C. Manning - Fort Collins CO
Assignee:
University Technology Corporation - Boulder CO
International Classification:
A61K 910, A61K 4734
US Classification:
424484
Abstract:
Pharmaceutical compositions for the delivery of pharmacologically active proteins are provided by the present invention. The compositions of the present invention comprise a polymeric matrix having thermal gelation properties in which is incorporated a discrete suspension of at least one biologically active macromolecular polypeptide which retains greater than 90 percent of its biological activity. Furthermore, the concentration of the macromolecular polypeptide is greater than 0. 5 percent by weight of the composition.
High-Pressure Inclusion Body Solubilization And Protease Clipping Of Recombinant Fusion Proteins
US Patent:
7829681, Nov 9, 2010
Filed:
Apr 7, 2008
Appl. No.:
12/098877
Inventors:
Matthew B. Seefeldt - Boulder CO, US
Lyndal K. Hesterberg - Boulder CO, US
Theodore W. Randolph - Niwot CO, US
John F. Carpenter - Littleton CO, US
Lyndal K. Hesterberg - Boulder CO, US
Theodore W. Randolph - Niwot CO, US
John F. Carpenter - Littleton CO, US
Assignee:
Barofold Inc. - Aurora CO
International Classification:
C07K 14/00, C12N 9/48, C12P 21/04
US Classification:
530427, 435212, 435 697
Abstract:
Described herein are methods for the solubilization and proteolytic cleavage of fusion protein aggregates, including autocatalytic fusion proteins, at pressures greater than atmospheric pressure to yield soluble target polypeptides.
Methods For Protein Refolding
US Patent:
8329878, Dec 11, 2012
Filed:
Apr 17, 2009
Appl. No.:
12/425729
Inventors:
Theodore W. Randolph - Niwot CO, US
John F. Carpenter - Littleton CO, US
Richard J. St. John - San Francisco CA, US
Jonathan N. Webb - Zionsville IN, US
John F. Carpenter - Littleton CO, US
Richard J. St. John - San Francisco CA, US
Jonathan N. Webb - Zionsville IN, US
Assignee:
Barofold Inc. - Aurora CO
International Classification:
C07K 1/02, C12N 9/00
US Classification:
530427, 435183
Abstract:
The present invention discloses improved methods of disaggregating protein aggregates, and refolding denatured proteins, using high pressure. In particular, the present invention provides for the use of agitation, high temperature, “stepped” depressurization, dialysis and dilution under pressure to increase the speed and extent of aggregate dissolution and protein refolding.
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