Inventors:
Bruce Rittmann - Tempe AZ, US
Rosa Krajmalnik-Brown - Chandler AZ, US
Husen Zhang - Tempe AZ, US
John Dibaise - Scottsdale AZ, US
Michael Crowell - Fountain Hills AZ, US
Assignee:
ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY - Tempe AZ
International Classification:
A61K 45/00
US Classification:
424 9341, 4352527, 4352521, 435243, 540457
Abstract:
The present invention provides for microbial compositions and methods for reducing the concentration of short-chain fatty acids in the gut as a way to reduce energy uptake and manage obesity. More specifically, the invention provides for decreasing short-chain fatty acids available for absorption in the human gut, such as acetate, using one or more of: a probiotic including a homo-acetogenic, acetate oxidizing bacterium that converts acetate to H; a probiotic including an acetoclastic methanogen; a microbial electrolysis cell comprising a homo-acetogenic bacterium and/or an acetoclastic methanogen; a prebiotic that enhances the growth or function of acetate-scavenging microbiota; or a highly selective antibiotic that targets H-oxidizing methanogens.