Inventors:
Alex W. Tong - Dallas TX, US
Yu An Zhang - Plano TX, US
John J. Nemunaitis - Dallas TX, US
Yuqiao Shen - Orinda CA, US
Po-hsun Chen - Addison TX, US
Shirley K. Samuel - Irving TX, US
Assignee:
BAYLOR RESEARCH INSTITUTE - Dallas TX
MUREX PHARMACEUTICALS - Dallas TX
BAYLOR UNIVERSITY - Waco TX
International Classification:
A61K 48/00, C12N 15/861
Abstract:
The present invention includes compositions and methods for the knockdown of one or more genes to a target cell in need of gene therapy by using an siRNA transgene that is integrated into a replication-competent, oncolytic adenovirus.