JOHN J MASIZ
Broker in Topsfield, MA
License number
Massachusetts 136765
Issued Date
Sep 1, 1989
Expiration Date
Mar 19, 1996
Type
Broker
Address
Address
Topsfield, MA 01983
Professional information
Transdermal Drug Delivery Using An Osmolyte And Vasoactive Agent
US Patent:
2010007, Mar 25, 2010
Filed:
Sep 22, 2009
Appl. No.:
12/564841
Inventors:
Stephen G. Carter - Andover MA, US
Zhen Zhu - Andover MA, US
Kanu Patel - Londonderry NH, US
John J. Masiz - Topsfield MA, US
Zhen Zhu - Andover MA, US
Kanu Patel - Londonderry NH, US
John J. Masiz - Topsfield MA, US
Assignee:
BIOCHEMICS, INC. - Danvers MA
International Classification:
A61K 31/426, A61K 31/05, A61K 31/19, A61P 43/00
US Classification:
514365, 514736, 514568
Abstract:
A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.
Solution-Based Transdermal Drug Delivery System
US Patent:
6635274, Oct 21, 2003
Filed:
Oct 27, 2000
Appl. No.:
09/698483
Inventors:
John J. Masiz - Topsfield MA
Stephen G. Carter - Andover MA
Stephen G. Carter - Andover MA
Assignee:
BioChemics, Inc. - Danvers MA
International Classification:
A61F 1300
US Classification:
424449, 424447
Abstract:
An efficient transdermal delivery system for delivering an active ingredient to the blood supply of a living body, comprising a vasodilator, an active ingredient, and a permeation enhancer for the active ingredient. The components of this mixture are combined in a manner that dissolves them into solution, eliminating the need for a polymeric binding agent and thus diminishing the total molecular weight of the mixture and increasing the penetration and delivery efficiency of the active drug molecules.
Control Of Blood Vessel Physiology To Treat Skin Disorders
US Patent:
2013024, Sep 19, 2013
Filed:
Jan 3, 2013
Appl. No.:
13/733247
Inventors:
John J. Masiz - Topsfield MA, US
Laura Stephens - Danvers MA, US
Zhen Zhu - Andover MA, US
Kanu Patel - Londonderry NH, US
David H. Donabedian - Pawtucket RI, US
Laura Stephens - Danvers MA, US
Zhen Zhu - Andover MA, US
Kanu Patel - Londonderry NH, US
David H. Donabedian - Pawtucket RI, US
Assignee:
BIOCHEMICS, INC. - Danvers MA
International Classification:
A61M 37/00, A61K 31/4164, A61K 31/455, A61N 7/00, A61K 31/425, A61K 31/137, A61K 31/522, A61N 5/06, A61K 31/198, A61K 31/295
US Classification:
604 22, 604501, 604500
Abstract:
In a method for treating an affected skin region of a patient having a skin disorder, a vasodilation composition is applied to an affected skin region of a patient, the affected skin region exhibiting a skin disorder characterized by at least one abnormal blood vessel, and the affected skin region is then treated so as to non-invasively disrupt tissue architecture, e.g., by inducing ischemia, of the at least one abnormal blood vessel. A vasoconstriction composition can then be applied to the skin region to cause vasoconstriction of the at least one blood vessel in order to promote healing.
Methods And Compositions For Tattoo Removal
US Patent:
2010014, Jun 10, 2010
Filed:
Dec 4, 2009
Appl. No.:
12/631698
Inventors:
Stephen G. Carter - Andover MA, US
Zhen Zhu - Andover MA, US
Kanu Patel - Londonderry NH, US
Diane L. Kozwich - Nottingham NH, US
Laura Stephens - Danvers MA, US
John J. Masiz - Topsfield MA, US
David H. Donabedian - Pawtucket RI, US
Zhen Zhu - Andover MA, US
Kanu Patel - Londonderry NH, US
Diane L. Kozwich - Nottingham NH, US
Laura Stephens - Danvers MA, US
John J. Masiz - Topsfield MA, US
David H. Donabedian - Pawtucket RI, US
Assignee:
BioChemics, Inc. - Danvers MA
International Classification:
A61M 37/00, A61K 8/18, A61Q 19/00
US Classification:
604 20, 424 62
Abstract:
Methods and formulations for removing a tattoo by using a cell disrupter in combination with a vasodilator, and optionally one or more of an osmotic modifying agent, a chelation agent, and an occlusive modifying agent. Embodiments optionally further include using one or more of an antibiotic, anesthetic, penetration enhancer, excipient, carrier and vehicle.
Control Of Blood Vessel Physiology To Treat Skin Disorders
US Patent:
8367122, Feb 5, 2013
Filed:
Jun 11, 2009
Appl. No.:
12/483073
Inventors:
Laura Stephens - Danvers MA, US
John J. Masiz - Topsfield MA, US
Stephen G. Carter - Andover MA, US
Zhen Zhu - Tewksbury MA, US
Kanu Patel - Londonderry NH, US
John J. Masiz - Topsfield MA, US
Stephen G. Carter - Andover MA, US
Zhen Zhu - Tewksbury MA, US
Kanu Patel - Londonderry NH, US
Assignee:
BioChemics, Inc. - Danvers MA
International Classification:
A61K 36/886
US Classification:
424725, 424744, 424401, 607 1
Abstract:
In a method for treating an affected skin region of a patient having a skin disorder, a vasodilation composition is applied to an affected skin region of a patient, the affected skin region exhibiting a skin disorder characterized by at least one abnormal blood vessel, and the affected skin region is then treated so as to non-invasively disrupt tissue architecture, e. g. , by inducing ischemia, of the at least one abnormal blood vessel. A vasoconstriction composition can then be applied to the skin region to cause vasoconstriction of the at least one blood vessel in order to promote healing.
Molecular Transdermal Transport System
US Patent:
5645854, Jul 8, 1997
Filed:
Oct 12, 1995
Appl. No.:
8/542068
Inventors:
John J. Masiz - Topsfield MA
International Classification:
A61F 1300
US Classification:
424449
Abstract:
An efficient transdermal delivery system for delivering an active ingredient to the blood supply of a living body, comprising a vasodilator and/or topical counter irritant, an active ingredient, a permeation enhancer for the active ingredient, and a water soluble gum for binding the foregoing. A non-breathable layer also can be used for controlling the microenvironment at the transport site. Compression can be used to further enhance the blood supply at the transport site.
Molecular Transdermal Transport System
US Patent:
5853751, Dec 29, 1998
Filed:
Jun 9, 1997
Appl. No.:
8/871156
Inventors:
John J. Masiz - Topsfield MA
International Classification:
A61F 1300
US Classification:
424449
Abstract:
An efficient transdermal delivery system for delivering an active ingredient to the blood supply of a living body, comprising a vasodilator, an active ingredient, a permeation enhancer for the active ingredient, and a water soluble gum for binding the foregoing. A non-breathable layer also can be used for controlling the microenvironment at the transport site. Compression can be used to further enhance the blood supply at the transport site.
Molecular Transdermal Transport System
US Patent:
5460821, Oct 24, 1995
Filed:
Apr 13, 1994
Appl. No.:
8/227365
Inventors:
John J. Masiz - Topsfield MA
International Classification:
A61F 1300
US Classification:
424449
Abstract:
An efficient transdermal delivery system for delivering an active ingredient to the blood supply of a living body, comprising a vasodilator and/or topical counter irritant, an active ingredient, a permeation enhancer for the active ingredient, and a water soluble gum for binding the foregoing. A non-breathable layer also can be used for controlling the microenvironment at the transport site. Compression can be used to further enhance the blood supply at the transport site.