JOHN J KEARNS
Engineering in Princeton, NJ
License number
Massachusetts 31399
Issued Date
Jul 29, 1983
Expiration Date
Jun 30, 2004
Type
Chemical Engineer
Address
Address
Princeton, NJ 08540
Professional information
Methods Of Preparing Low-Toxicity Drug-Lipid Complexes
US Patent:
6406713, Jun 18, 2002
Filed:
Apr 28, 1995
Appl. No.:
08/430661
Inventors:
Andrew S. Janoff - Yardley PA
Thomas D. Madden - Vancouver, CA
Pieter R. Cullis - Vancouver, CA
John J. Kearns - Princeton NJ
Anthony G. Durning - Yardley PA
Thomas D. Madden - Vancouver, CA
Pieter R. Cullis - Vancouver, CA
John J. Kearns - Princeton NJ
Anthony G. Durning - Yardley PA
Assignee:
The Liposome Company, Inc. - Princeton NJ
International Classification:
A61K 9127
US Classification:
424450, 4284022, 264 41, 264 43
Abstract:
Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.
Process For Purification Of Phospholipids
US Patent:
5084215, Jan 28, 1992
Filed:
Oct 20, 1988
Appl. No.:
7/260156
Inventors:
John J. Kearns - Princeton NJ
Paul A. Tremblay - Hamilton NJ
Paul A. Tremblay - Hamilton NJ
Assignee:
The Liposome Company, Inc. - Princeton NJ
International Classification:
C11C 100
US Classification:
260403
Abstract:
A process for the separation and purification of individual phospholipids, especially phosphatidylcholine or lecithin and phosphatidylethanolaine, from mixtures containing members of the sub-class of phosphatides, incorporating methods of solvent extraction appropriate to the scale of the sample and utilizing an acetonitrile, acetonitrile-hydrocarbon, or acetonitrile-fluorocarbon solvent, which exhibit differential solubility properties towards the individual phospholipids.
Phospholipid Composition And Liposomes Made Therefrom
US Patent:
5429823, Jul 4, 1995
Filed:
Sep 9, 1994
Appl. No.:
8/303592
Inventors:
Paul A. Tremblay - Hamilton NJ
Robert L. Suddith - Robbinsville NJ
John J. Kearns - Princeton NJ
Robert L. Suddith - Robbinsville NJ
John J. Kearns - Princeton NJ
Assignee:
The Liposome Company, Inc. - Princeton NJ
International Classification:
A61K 9127, A61K 9133
US Classification:
424450
Abstract:
A composition having equal to or greater than about 97 percent by weight phosphatidylcholine and about equal to or less than about 3 percent by weight to about 0. 5% sphingomylin and equal to or less than about 0. 5% lysophosphatidylcholine (undetectable by UV at 205 nm) has been found to result in liposomes having improved stability. Methods for preparing the composition are disclosed whereby the phospholipids are extracted and then purified using silica chromatography.
Process For Purification Of Phospholipids
US Patent:
4714571, Dec 22, 1987
Filed:
Feb 6, 1985
Appl. No.:
6/698668
Inventors:
Paul A. Tremblay - Mercerville NJ
John J. Kearns - Princeton NJ
John J. Kearns - Princeton NJ
Assignee:
The Liposome Company, Inc. - Princeton NJ
International Classification:
C11C 100
US Classification:
260403
Abstract:
A process for the separation and purification of individual phospholipids, especially phosphatidylcholine or lecithin and phosphatidylethanolamine, from mixtures containing members of the sub-class of phosphatides, incorporating methods of solvent extraction appropriate to the scale of the sample and utilizing an acetonitrile, acetonitrile-hydrocarbon, or acetonitrile-fluorocarbon solvent, which exhibit differential solubility properties towards the individual phospholipids.
Phospholipid Composition
US Patent:
5783210, Jul 21, 1998
Filed:
May 24, 1995
Appl. No.:
8/453132
Inventors:
Paul A. Tremblay - Hamilton NJ
Robert L. Suddith - Robbinsville NJ
John J. Kearns - Princeton NJ
Robert L. Suddith - Robbinsville NJ
John J. Kearns - Princeton NJ
Assignee:
The Liposome Company, Inc. - Princeton NJ
International Classification:
A61K 9127
US Classification:
424450
Abstract:
A composition having equal to or greater than about 97 percent by weight phosphatidylcholine and about equal to or less than about 3 percent by weight to about 0. 5% sphingomylin and equal to or less than about 0. 5% lysophosphatidylcholine (undetectable by UV at 205 nm) has been found to result in liposomes having improved stability. Methods for preparing the composition are disclosed whereby the phospholipids are extracted and then purified using silica chromatography.
Low Toxicity Drug-Lipid Systems
US Patent:
5616334, Apr 1, 1997
Filed:
Apr 28, 1995
Appl. No.:
8/430699
Inventors:
Andrew S. Janoff - Yardley PA
Lawrence Boni - Monmouth Junction NJ
Thomas D. Madden - Vancouver, CA
Pieter R. Cullis - Vancouver, CA
Robert P. Lenk - Lambertville NJ
John J. Kearns - Princeton NJ
Anthony G. Durning - Yardley PA
Robert Klimchak - Flemington NJ
Joel Portnoff - Richboro PA
Lawrence Boni - Monmouth Junction NJ
Thomas D. Madden - Vancouver, CA
Pieter R. Cullis - Vancouver, CA
Robert P. Lenk - Lambertville NJ
John J. Kearns - Princeton NJ
Anthony G. Durning - Yardley PA
Robert Klimchak - Flemington NJ
Joel Portnoff - Richboro PA
Assignee:
The Liposome Company, Inc. - Princeton NJ
International Classification:
A01N 2532, A01N 5726, A61K 31685
US Classification:
424404
Abstract:
Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.
Lipid Matrix Carriers For Use In Drug Delivery Systems
US Patent:
4610868, Sep 9, 1986
Filed:
Mar 20, 1984
Appl. No.:
6/591576
Inventors:
Michael W. Fountain - Plainsboro NJ
Steven J. Weiss - Lawrenceville NJ
John J. Kearns - Princeton NJ
Alan L. Weiner - Plainsboro NJ
Mircea C. Popescu - Plainsboro NJ
Steven J. Weiss - Lawrenceville NJ
John J. Kearns - Princeton NJ
Alan L. Weiner - Plainsboro NJ
Mircea C. Popescu - Plainsboro NJ
Assignee:
The Liposome Company, Inc. - Princeton NJ
International Classification:
A61K 4300, A61K 4900
US Classification:
424 11
Abstract:
Lipid matrix carriers are described which provide for the sustained release of bioactive agents in vivo or in vitro. The properties of the lipid matrix carriers of the present invention include high entrapment efficiencies; release of entrapped compounds in their active form; biodegradability and avoidance of vascular occlusion in vivo; and avoidance of sequestration of the bioactive agent in the liver and spleen.
Process For Purification Of Phospholipids
US Patent:
4814111, Mar 21, 1989
Filed:
Nov 7, 1986
Appl. No.:
6/928508
Inventors:
John J. Kearns - Princeton NJ
Paul A. Tremblay - Mercerville NJ
Raymond J. Robey - Macungie PA
Swaminathan Sunder - Allentown PA
Paul A. Tremblay - Mercerville NJ
Raymond J. Robey - Macungie PA
Swaminathan Sunder - Allentown PA
Assignee:
Air Products and Chemicals, Inc. - Allentown PA
International Classification:
C11C 100
US Classification:
260403
Abstract:
A process for the separation and purification of individual phospholipids, especially phosphatidylcholine or lecithin and phosphatidylethanolamine, from mixtures containing members of the sub-class of phosphatides, incorporating methods of solvent extraction appropriate to the scale of the sample and utilizing an acetonitrile, acetonitrile-hydrocarbon, or acetonitrile-fluorocarbon solvent, which exhibit differential solubility properties towards the individual phospholipids.