Inventors:
Lloyd S. Gray - Charlottesville VA
Doris M. Haverstick - Charlottesville VA
John J. Densmore - Charlottesville VA
Gabor Szabo - Charlottesville VA
Assignee:
The University of Virginia Patents Foundation - Charlottesville VA
International Classification:
A61K 31502
Abstract:
The present invention provides methods for screening for voltage gated (VG)-selective inhibitors, novel VG-selective inhibitors, compositions containing the same, methods for inhibiting calcium entry into electrically non-excitable cells with said VG-selective inhibitors, methods for preventing proliferation of electrically non-excitable cells with said VG-selective inhibitors as well as methods of treating autoimmune diseases, preventing graft rejections, preventing apoptosis and treating cancer with the same.