Inventors:
Dennis Charney - Chappaqua NY, US
Sanjay Mathew - New York NY, US
Husseini Manji - Rockville MD, US
Carlos Zarate - Germantown MD, US
John Krystal - Woodbridge CT, US
Assignee:
MOUNT SINAI SCHOOL OF MEDICINE - New York NY
NATIONAL INSTITUTE OF HEALTH - Rockville MD
YALE UNIVERSITY SCHOOL OF MEDICINE - New Haven CT
International Classification:
A61K 31/135, A61K 33/14, A61K 36/00, A61M 11/00, A61M 5/00, A61P 25/24
US Classification:
514647000, 128200140, 424449000, 424722000, 424725000, 604046000
Abstract:
Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent or chronic depressive symptoms (>2 years).