JOHN GUY
Medical Practice in Gainesville, FL
License number
Pennsylvania MD020944E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Gainesville, FL 32610
Pennsylvania
Pennsylvania
Personal information
See more information about JOHN GUY at radaris.comName
Address
Phone
576 Lincoln Rd NE, Lake Placid, FL 33852
6000 Collins Ave APT 107, Miami Beach, FL 33140
5352 Hayden Blvd, Sarasota, FL 34232
505 Fernwood Ave, Folsom, PA 19033
525 W 15Th St, Tyrone, PA 16686
Organization information
See more information about JOHN GUY at bizstanding.comJohn Guy MD
1600 SW Archer Rd #2, Gainesville, FL 32610
Categories:
Ophthalmology Physicians & Surgeons
Phone:
(352) 392-3261 (Phone)
Professional information
See more information about JOHN GUY at trustoria.com
Reducing Cellular Dysfunction Caused By Mitochondrial Gene Mutations
Reducing Cellular Dysfunction Caused By Mitochondrial Gene Mutations
US Patent:
7405284, Jul 29, 2008
Filed:
Oct 17, 2003
Appl. No.:
10/687677
Inventors:
John Guy - Gainesville FL, US
Assignee:
University of Florida Research Foundation, Inc. - Gainesville FL
International Classification:
C07H 21/02, C07H 21/04, C12N 5/00, C12N 5/02, C12N 5/08
US Classification:
536 231, 435325, 435366, 435368
Abstract:
A synthetic, nuclear-encoded ND4 gene was linked to a mitochondrial targeting sequence and a FLAG epitope tag. This fusion construct was inserted into a rAAV vector. The ND4 fusion protein was expressed and imported into the mitochondria of cells harboring a mitochondrial DNA mutation (G11778A), where it restored cellular respiration.
Suppression Of Mitochondrial Oxidative Stress
Suppression Of Mitochondrial Oxidative Stress
US Patent:
2010004, Feb 18, 2010
Filed:
Oct 19, 2007
Appl. No.:
12/446878
Inventors:
John Guy - Gainesville FL, US
International Classification:
A61K 31/7088, C12N 15/00, C12N 5/10
US Classification:
514 44 R, 4353201, 435325, 435366, 435375
Abstract:
Compositions for suppressing and inhibiting mitochondrial oxidative stress. The compositions include a human mitochondrial superoxide dismutase (SOD2) gene. Methods of treating patients suffering from diseases or disorders associated with mitochondrial oxidative stress.
Mitochondrial Nucleic Acid Delivery Systems
Mitochondrial Nucleic Acid Delivery Systems
US Patent:
8278428, Oct 2, 2012
Filed:
Feb 18, 2008
Appl. No.:
12/526878
Inventors:
John Guy - Gainesville FL, US
Nicholas Muzyczka - Gainesville FL, US
Nicholas Muzyczka - Gainesville FL, US
International Classification:
C07H 21/02, C07H 21/04, A61K 48/00
US Classification:
536 231, 536 235, 514 44 R
Abstract:
Nucleic acid mitochondrial delivery systems are provided. These systems are important for delivery of genetic information to a mitochondrion and for treatment of mitochondrial related diseases.