JOHN GUY
Medical Practice in Gainesville, FL
License number
Pennsylvania MD020944E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Gainesville, FL 32610
Pennsylvania
Pennsylvania
Organization information
See more information about JOHN GUY at bizstanding.comJohn Guy MD
1600 SW Archer Rd #2, Gainesville, FL 32610
Categories:
Ophthalmology Physicians & Surgeons
Phone:
(352) 392-3261 (Phone)
Professional information
Reducing Cellular Dysfunction Caused By Mitochondrial Gene Mutations
US Patent:
7405284, Jul 29, 2008
Filed:
Oct 17, 2003
Appl. No.:
10/687677
Inventors:
John Guy - Gainesville FL, US
Assignee:
University of Florida Research Foundation, Inc. - Gainesville FL
International Classification:
C07H 21/02, C07H 21/04, C12N 5/00, C12N 5/02, C12N 5/08
US Classification:
536 231, 435325, 435366, 435368
Abstract:
A synthetic, nuclear-encoded ND4 gene was linked to a mitochondrial targeting sequence and a FLAG epitope tag. This fusion construct was inserted into a rAAV vector. The ND4 fusion protein was expressed and imported into the mitochondria of cells harboring a mitochondrial DNA mutation (G11778A), where it restored cellular respiration.
Suppression Of Mitochondrial Oxidative Stress
US Patent:
2010004, Feb 18, 2010
Filed:
Oct 19, 2007
Appl. No.:
12/446878
Inventors:
John Guy - Gainesville FL, US
International Classification:
A61K 31/7088, C12N 15/00, C12N 5/10
US Classification:
514 44 R, 4353201, 435325, 435366, 435375
Abstract:
Compositions for suppressing and inhibiting mitochondrial oxidative stress. The compositions include a human mitochondrial superoxide dismutase (SOD2) gene. Methods of treating patients suffering from diseases or disorders associated with mitochondrial oxidative stress.
Mitochondrial Nucleic Acid Delivery Systems
US Patent:
8278428, Oct 2, 2012
Filed:
Feb 18, 2008
Appl. No.:
12/526878
Inventors:
John Guy - Gainesville FL, US
Nicholas Muzyczka - Gainesville FL, US
Nicholas Muzyczka - Gainesville FL, US
International Classification:
C07H 21/02, C07H 21/04, A61K 48/00
US Classification:
536 231, 536 235, 514 44 R
Abstract:
Nucleic acid mitochondrial delivery systems are provided. These systems are important for delivery of genetic information to a mitochondrion and for treatment of mitochondrial related diseases.