Inventors:
Julien P. H. Verheyden - Los Altos CA
John C. Martin - Redwood City CA
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
C07D47302, A61K 3152
Abstract:
Compounds useful as antiviral agents are defined by the following formula: ##STR1## wherein R. sup. 1 is hydrogen, --C(Y)OR. sup. 7 or --C(O)NHR. sup. 7 wherein R. sup. 7 is alkyl of one to twelve carbon atoms, alkenyl of two to twelve carbon atoms, cyclopentyl, cyclohexyl, phenyl or benzyl;
R. sup. 2 is --C(Y)OR. sup. 7 or --C(O)NHR. sup. 7 wherein R. sup. 7 is as defined above;
Y is oxygen or sulfur;
R. sup. 3 is hydrogen, halo, thio, lower alkylthio of one to six carbon atoms, azido, NR. sup. 9 R. sup. 10 wherein R. sup. 9 and R. sup. 10 are independently hydrogen or lower alkyl of one to six carbon atoms or --NHC(O)R. sup. 8 wherein R. sup. 8 is hydrogen, alkyl of one to nineteen carbon atoms or 1-adamantyl; and
(a) R. sup. 6 is hydrogen, halo, lower alkoxy of one to six carbon atoms, azido, thio, lower alkylthio of one to six carbon atoms, --NR. sup. 9 R. sup. 10 wherein R. sup. 9 and R. sup.